Regulatory Network in Protein Phosphorylation
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The kinase complement of the human genome, the kinome, provided a start point for comprehensive investigation of protein phosphorylation. Manning et al. identified 518 protein kinase genes and 106 protein kinase pseudogenes in human (Manning et al., 2002 Science). Most protein kinases contain a conserved catalytic domain belonging to the eukaryotic protein kinase (ePK) superfamily (all other protein kinases are classified as atypical protein kinases, or aPKs). ePKs are classified into 7 major groups, including AGC, CAMK, CK1, CMGC, STE, TK, and TKL, and are subdivided into families, and sometimes subfamilies, based on the sequence of their ePK domains. All 518 human kinases are listed as following, users can clikc into the URL link to investigate the detail information about the kinase and their substrates.

[All kinases] [Kinase families] [Tree view of kinase families]

No.KinaseGroupFamilySubfamilyGene SymbolDescription
1AKT1AGCAkt AKT1 v-akt murine thymoma viral oncogene homolog 1 
2AKT2AGCAkt AKT2 v-akt murine thymoma viral oncogene homolog 2 
3AKT3AGCAkt AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) 
4CRIKAGCDMPKCRIK CIT citron (rho-interacting, serine/threonine kinase 21) 
5DMPK1AGCDMPKGEK DMPK dystrophia myotonica-protein kinase 
6MRCKaAGCDMPKGEK CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 
7MRCKbAGCDMPKGEK CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 
8DMPK2AGCDMPKGEK CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 
9ROCK1AGCDMPKROCK ROCK1 Rho-associated, coiled-coil containing protein kinase 1 
10ROCK2AGCDMPKROCK ROCK2 Rho-associated, coiled-coil containing protein kinase 2 
11BARK1AGCGRKBARK ADRBK1 adrenergic, beta, receptor kinase 1 
12BARK2AGCGRKBARK ADRBK2 adrenergic, beta, receptor kinase 2 
13GPRK4AGCGRKGRK GRK4 G protein-coupled receptor kinase 4 
14GPRK5AGCGRKGRK GRK5 G protein-coupled receptor kinase 5 
15GPRK6AGCGRKGRK GRK6 G protein-coupled receptor kinase 6 
16RHOKAGCGRKGRK GRK1 G protein-coupled receptor kinase 1 
17GPRK7AGCGRKGRK GRK7 G protein-coupled receptor kinase 7 
18MAST1AGCMASTMAST MAST1 microtubule associated serine/threonine kinase 1 
19MAST3AGCMASTMAST MAST3 microtubule associated serine/threonine kinase 3 
20MAST2AGCMASTMAST MAST2 microtubule associated serine/threonine kinase 2 
21MAST4AGCMASTMAST LOC375449 similar to microtubule associated testis specific serine/threonine protein kinase 
22MASTLAGCMASTMASTL MASTL microtubule associated serine/threonine kinase-like 
23LATS1AGCNDR LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila) 
24NDR1AGCNDR STK38 serine/threonine kinase 38 
25NDR2AGCNDR STK38L serine/threonine kinase 38 like 
26LATS2AGCNDR LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 
27PDK1AGCPDK1 PDPK1 3-phosphoinositide dependent protein kinase-1 
28PKACaAGCPKA PRKACA protein kinase, cAMP-dependent, catalytic, alpha 
29PKACbAGCPKA PRKACB protein kinase, cAMP-dependent, catalytic, beta 
30PKACgAGCPKA PRKACG protein kinase, cAMP-dependent, catalytic, gamma 
31PRKXAGCPKA PRKX protein kinase, X-linked 
32PRKYAGCPKA PRKY protein kinase, Y-linked 
33PKCaAGCPKCAlpha PRKCA protein kinase C, alpha 
34PKCbAGCPKCAlpha PRKCB1 protein kinase C, beta 1 
35PKCgAGCPKCAlpha PRKCG protein kinase C, gamma 
36PKCdAGCPKCDelta PRKCD protein kinase C, delta 
37PKCtAGCPKCDelta PRKCQ protein kinase C, theta 
38PKCeAGCPKCEta PRKCE protein kinase C, epsilon 
39PKChAGCPKCEta PRKCH protein kinase C, eta 
40PKCiAGCPKCIota PRKCI protein kinase C, iota 
41PKCzAGCPKCIota PRKCZ protein kinase C, zeta 
42PKG1AGCPKG PRKG1 protein kinase, cGMP-dependent, type I 
43PKG2AGCPKG PRKG2 protein kinase, cGMP-dependent, type II 
44PKN1AGCPKN PKN1 protein kinase N1 
45PKN2AGCPKN PKN2 protein kinase N2 
46PKN3AGCPKN PKN3 protein kinase N3 
47MSK2AGCRSKMSK RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 
48MSK1AGCRSKMSK RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 
49p70S6KAGCRSKp70 RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 
50p70S6KbAGCRSKp70 RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 
51RSK3AGCRSKRSK RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 
52RSK1AGCRSKRSK RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 
53RSK2AGCRSKRSK RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 
54RSK4AGCRSKRSK RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 
55RSKL1AGCRSKL RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 
56RSKL2AGCRSKL RPS6KL1 ribosomal protein S6 kinase-like 1 
57SgK494AGCRSKR FLJ25006 hypothetical protein FLJ25006 
58SGK1AGCSGK SGK serum/glucocorticoid regulated kinase 
59SGK2AGCSGK SGK2 serum/glucocorticoid regulated kinase 2 
60SGK3AGCSGK SGK3 serum/glucocorticoid regulated kinase family, member 3 
61YANK2AGCYANK STK32B serine/threonine kinase 32B 
62YANK1AGCYANK STK32A serine/threonine kinase 32A 
63YANK3AGCYANK STK32C serine/threonine kinase 32C 
64ADCK3AtypicalABC1ABC1-A CABC1 chaperone, ABC1 activity of bc1 complex homolog (S. pombe) 
65ADCK4AtypicalABC1ABC1-A ADCK4 aarF domain containing kinase 4 
66ADCK1AtypicalABC1ABC1-B ADCK1 aarF domain containing kinase 1 
67ADCK5AtypicalABC1ABC1-B ADCK5 aarF domain containing kinase 5 
68ADCK2AtypicalABC1ABC1-C ADCK2 aarF domain containing kinase 2 
69AlphaK1AtypicalAlphaAlpha-Unclassified ALPK3 alpha-kinase 3 
70AlphaK3AtypicalAlphaAlpha-Unclassified ALPK1 alpha-kinase 1 
71AlphaK2AtypicalAlphaAlpha-Unclassified ALPK2 alpha-kinase 2 
72ChaK1AtypicalAlphaChaK TRPM7 transient receptor potential cation channel, subfamily M, member 7 
73ChaK2AtypicalAlphaChaK TRPM6 transient receptor potential cation channel, subfamily M, member 6 
74eEF2KAtypicalAlphaeEF2K EEF2K eukaryotic elongation factor-2 kinase 
75BCRAtypicalBCR BCR breakpoint cluster region 
76BRDTAtypicalBRD BRDT bromodomain, testis-specific 
77BRD2AtypicalBRD BRD2 bromodomain containing 2 
78BRD3AtypicalBRD BRD3 bromodomain containing 3 
79BRD4AtypicalBRD BRD4 bromodomain containing 4 
80FASTKAtypicalFAST FASTK Fas-activated serine/threonine kinase 
81G11AtypicalG11 STK19 serine/threonine kinase 19 
82H11AtypicalH11 HSPB8 heat shock 22kDa protein 8 
83BCKDKAtypicalPDHKBCKDK BCKDK branched chain ketoacid dehydrogenase kinase 
84PDHK1AtypicalPDHKPDHK PDK1 pyruvate dehydrogenase kinase, isozyme 1 
85PDHK2AtypicalPDHKPDHK PDK2 pyruvate dehydrogenase kinase, isozyme 2 
86PDHK3AtypicalPDHKPDHK PDK3 pyruvate dehydrogenase kinase, isozyme 3 
87PDHK4AtypicalPDHKPDHK PDK4 pyruvate dehydrogenase kinase, isozyme 4 
88ATMAtypicalPIKKATM ATM ataxia telangiectasia mutated (includes complementation groups A, C and D) 
89ATRAtypicalPIKKATR ATR ataxia telangiectasia and Rad3 related 
90DNAPKAtypicalPIKKDNAPK PRKDC protein kinase, DNA-activated, catalytic polypeptide 
91FRAPAtypicalPIKKFRAP FRAP1 FK506 binding protein 12-rapamycin associated protein 1 
92SMG1AtypicalPIKKSMG1 SMG1 PI-3-kinase-related kinase SMG-1 
93TRRAPAtypicalPIKKTRRAP TRRAP transformation/transcription domain-associated protein 
94RIOK1AtypicalRIORIO1 RIOK1 RIO kinase 1 (yeast) 
95RIOK2AtypicalRIORIO2 RIOK2 RIO kinase 2 (yeast) 
96RIOK3AtypicalRIORIO3 RIOK3 RIO kinase 3 (yeast) 
97TAF1AtypicalTAF1 TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 
98TAF1LAtypicalTAF1 TAF1L TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa 
99TIF1aAtypicalTIF1 TRIM24 tripartite motif-containing 24 
100TIF1bAtypicalTIF1 TRIM28 tripartite motif-containing 28 
101TIF1gAtypicalTIF1 TRIM33 tripartite motif-containing 33 
102CaMK4CAMKCAMK1 CAMK4 calcium/calmodulin-dependent protein kinase IV 
103CaMK1aCAMKCAMK1 CAMK1 calcium/calmodulin-dependent protein kinase I 
104CaMK1dCAMKCAMK1 CAMK1D calcium/calmodulin-dependent protein kinase ID 
105CaMK1gCAMKCAMK1 CAMK1G calcium/calmodulin-dependent protein kinase IG 
106CaMK1bCAMKCAMK1 PNCK pregnancy upregulated non-ubiquitously expressed CaM kinase 
107CaMK2aCAMKCAMK2 CAMK2A calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha 
108CaMK2bCAMKCAMK2 CAMK2B calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 
109CaMK2dCAMKCAMK2 CAMK2D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 
110CaMK2gCAMKCAMK2 CAMK2G calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 
111AMPKa1CAMKCAMKLAMPK PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 
112AMPKa2CAMKCAMKLAMPK PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 
113BRSK2CAMKCAMKLBRSK BRSK2 BR serine/threonine kinase 2 
114BRSK1CAMKCAMKLBRSK BRSK1 BR serine/threonine kinase 1 
115CHK1CAMKCAMKLCHK1 CHEK1 CHK1 checkpoint homolog (S. pombe) 
116HUNKCAMKCAMKLHUNK HUNK hormonally upregulated Neu-associated kinase 
117LKB1CAMKCAMKLLKB STK11 serine/threonine kinase 11 
118MARK2CAMKCAMKLMARK MARK2 MAP/microtubule affinity-regulating kinase 2 
119MARK1CAMKCAMKLMARK MARK1 MAP/microtubule affinity-regulating kinase 1 
120MARK3CAMKCAMKLMARK MARK3 MAP/microtubule affinity-regulating kinase 3 
121MARK4CAMKCAMKLMARK MARK4 MAP/microtubule affinity-regulating kinase 4 
122MELKCAMKCAMKLMELK MELK maternal embryonic leucine zipper kinase 
123NIM1CAMKCAMKLNIM1 MGC42105 hypothetical protein MGC42105 
124NuaK1CAMKCAMKLNuaK NUAK1 NUAK family, SNF1-like kinase, 1 
125NuaK2CAMKCAMKLNuaK NUAK2 NUAK family, SNF1-like kinase, 2 
126PASKCAMKCAMKLPASK PASK PAS domain containing serine/threonine kinase 
127QIKCAMKCAMKLQIK SNF1LK2 SNF1-like kinase 2 
131STK33CAMKCAMK-Unique STK33 serine/threonine kinase 33 
132VACAMKLCAMKCAMK-Unique CAMKV CaM kinase-like vesicle-associated 
133CASKCAMKCASK CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 
134DAPK1CAMKDAPKDAPK DAPK1 death-associated protein kinase 1 
135DAPK3CAMKDAPKDAPK DAPK3 death-associated protein kinase 3 
136DAPK2CAMKDAPKDAPK DAPK2 death-associated protein kinase 2 
137DRAK2CAMKDAPKDRAK STK17B serine/threonine kinase 17b (apoptosis-inducing) 
138DRAK1CAMKDAPKDRAK STK17A serine/threonine kinase 17a (apoptosis-inducing) 
139DCLK1CAMKDCAMKL DCAMKL1 doublecortin and CaM kinase-like 1 
140DCLK3CAMKDCAMKL DCAMKL3 doublecortin and CaM kinase-like 3 
141DCLK2CAMKDCAMKL DCAMKL2 doublecortin and CaM kinase-like 2 
142MAPKAPK3CAMKMAPKAPKMAPKAPK MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 
143MAPKAPK5CAMKMAPKAPKMAPKAPK MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 
144MAPKAPK2CAMKMAPKAPKMAPKAPK MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 
145MNK2CAMKMAPKAPKMNK MKNK2 MAP kinase interacting serine/threonine kinase 2 
146MNK1CAMKMAPKAPKMNK MKNK1 MAP kinase interacting serine/threonine kinase 1 
147smMLCKCAMKMLCK MYLK myosin, light chain kinase 
149skMLCKCAMKMLCK MYLK2 myosin light chain kinase 2, skeletal muscle 
151SgK085CAMKMLCK RP11-145H9.1 hypothetical protein LOC340156 
152PHKg1CAMKPHK PHKG1 phosphorylase kinase, gamma 1 (muscle) 
153PHKg2CAMKPHK PHKG2 phosphorylase kinase, gamma 2 (testis) 
154PIM1CAMKPIM PIM1 pim-1 oncogene 
155PIM2CAMKPIM PIM2 pim-2 oncogene 
156PIM3CAMKPIM PIM3 pim-3 oncogene 
157PKD1CAMKPKD PRKD1 protein kinase D1 
158PKD3CAMKPKD PRKD3 protein kinase D3 
159PKD2CAMKPKD PRKD2 protein kinase D2 
160PSKH1CAMKPSK PSKH1 protein serine kinase H1 
161PSKH2CAMKPSK PSKH2 protein serine kinase H2 
162CHK2CAMKRAD53 CHEK2 CHK2 checkpoint homolog (S. pombe) 
163SgK495CAMKSgK495 STK40 serine/threonine kinase 40 
164Trb1CAMKTrbl TRIB1 tribbles homolog 1 (Drosophila) 
165Trb2CAMKTrbl TRIB2 tribbles homolog 2 (Drosophila) 
166Trb3CAMKTrbl TRIB3 tribbles homolog 3 (Drosophila) 
167ObscnCAMKTrio OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 
168SPEGCAMKTrio LOC729871 similar to aortic preferentially expressed gene 1 
169TrioCAMKTrio TRIO triple functional domain (PTPRF interacting) 
170TradCAMKTrio KALRN kalirin, RhoGEF kinase 
171TSSK2CAMKTSSK TSSK2 testis-specific serine kinase 2 
172TSSK3CAMKTSSK TSSK3 testis-specific serine kinase 3 
173TSSK1CAMKTSSK TSSK1B testis-specific serine kinase 1B 
174SSTKCAMKTSSK TSSK6 testis-specific serine kinase 6 
175TSSK4CAMKTSSK TSSK4 testis-specific serine kinase 4 
176CK1aCK1CK1CK1-A CSNK1A1 casein kinase 1, alpha 1 
177CK1a2CK1CK1CK1-A CSNK1A1L casein kinase 1, alpha 1-like 
178CK1dCK1CK1CK1-D CSNK1D casein kinase 1, delta 
179CK1eCK1CK1CK1-D CSNK1E casein kinase 1, epsilon 
180CK1g2CK1CK1CK1-G CSNK1G2 casein kinase 1, gamma 2 
181CK1g3CK1CK1CK1-G CSNK1G3 casein kinase 1, gamma 3 
182CK1g1CK1CK1CK1-G CSNK1G1 casein kinase 1, gamma 1 
183TTBK1CK1TTBK TTBK1 tau tubulin kinase 1 
184TTBK2CK1TTBK TTBK2 tau tubulin kinase 2 
185VRK1CK1VRK VRK1 vaccinia related kinase 1 
186VRK2CK1VRK VRK2 vaccinia related kinase 2 
187VRK3CK1VRK VRK3 vaccinia related kinase 3 
188CCRKCMGCCDKCCRK CCRK cell cycle related kinase 
189CDC2CMGCCDKCDC2 CDC2 cell division cycle 2, G1 to S and G2 to M 
190CDK2CMGCCDKCDC2 CDK2 cyclin-dependent kinase 2 
191CDK3CMGCCDKCDC2 CDK3 cyclin-dependent kinase 3 
192CDK10CMGCCDKCDK10 CDK10 cyclin-dependent kinase (CDC2-like) 10 
193CDK4CMGCCDKCDK4 CDK4 cyclin-dependent kinase 4 
194CDK6CMGCCDKCDK4 CDK6 cyclin-dependent kinase 6 
195CDK5CMGCCDKCDK5 CDK5 cyclin-dependent kinase 5 
196CDK7CMGCCDKCDK7 CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) 
197CDK8CMGCCDKCDK8 CDK8 cyclin-dependent kinase 8 
198CDK11CMGCCDKCDK8 CDC2L6 cell division cycle 2-like 6 (CDK8-like) 
199CDK9CMGCCDKCDK9 CDK9 cyclin-dependent kinase 9 (CDC2-related kinase) 
200CHEDCMGCCDKCRK7 CDC2L5 cell division cycle 2-like 5 (cholinesterase-related cell division controller) 
201CRK7CMGCCDKCRK7 CRKRS Cdc2-related kinase, arginine/serine-rich 
206PFTAIRE2CMGCCDKPFTAIRE ALS2CR7 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7 
207PITSLRECMGCCDKPITSLRE CDC2L2 cell division cycle 2-like 2 (PITSLRE proteins) 
208CDKL5CMGCCDKL CDKL5 cyclin-dependent kinase-like 5 
209CDKL1CMGCCDKL CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 
210CDKL2CMGCCDKL CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 
211CDKL3CMGCCDKL CDKL3 cyclin-dependent kinase-like 3 
212CDKL4CMGCCDKL CDKL4 cyclin-dependent kinase-like 4 
213CK2a1CMGCCK2 CSNK2A1 casein kinase 2, alpha 1 polypeptide 
214CK2a2CMGCCK2 CSNK2A2 casein kinase 2, alpha prime polypeptide 
215CLK1CMGCCLK CLK1 CDC-like kinase 1 
216CLK2CMGCCLK CLK2 CDC-like kinase 2 
217CLK3CMGCCLK CLK3 CDC-like kinase 3 
218CLK4CMGCCLK CLK4 CDC-like kinase 4 
219DYRK1ACMGCDYRKDYRK1 DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 
220DYRK1BCMGCDYRKDYRK1 DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 
221DYRK3CMGCDYRKDYRK2 DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 
222DYRK2CMGCDYRKDYRK2 DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 
223DYRK4CMGCDYRKDYRK2 DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 
224HIPK3CMGCDYRKHIPK HIPK3 homeodomain interacting protein kinase 3 
225HIPK2CMGCDYRKHIPK HIPK2 homeodomain interacting protein kinase 2 
226HIPK4CMGCDYRKHIPK HIPK4 homeodomain interacting protein kinase 4 
227HIPK1CMGCDYRKHIPK HIPK1 homeodomain interacting protein kinase 1 
228PRP4CMGCDYRKPRP4 PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast) 
229GSK3ACMGCGSK GSK3A glycogen synthase kinase 3 alpha 
230GSK3BCMGCGSK GSK3B glycogen synthase kinase 3 beta 
231Erk2(MAPK1)CMGCMAPKERK1 MAPK1 mitogen-activated protein kinase 1 
232Erk1(MAPK3)CMGCMAPKERK1 MAPK3 mitogen-activated protein kinase 3 
233Erk4(MAPK4)CMGCMAPKERK3 MAPK4 mitogen-activated protein kinase 4 
234Erk3(MAPK6)CMGCMAPKERK3 MAPK6 mitogen-activated protein kinase 6 
235Erk5(MAPK7)CMGCMAPKERK5 MAPK7 mitogen-activated protein kinase 7 
236Erk7(MAPK15)CMGCMAPKERK7 MAPK15 mitogen-activated protein kinase 15 
237JNK1(MAPK8)CMGCMAPKJNK MAPK8 mitogen-activated protein kinase 8 
238JNK2(MAPK9)CMGCMAPKJNK MAPK9 mitogen-activated protein kinase 9 
239JNK3(MAPK10)CMGCMAPKJNK MAPK10 mitogen-activated protein kinase 10 
240NLKCMGCMAPKnmo NLK nemo-like kinase 
241p38a(MAPK14)CMGCMAPKp38 MAPK14 mitogen-activated protein kinase 14 
242p38b(MAPK11)CMGCMAPKp38 MAPK11 mitogen-activated protein kinase 11 
243p38d(MAPK13)CMGCMAPKp38 MAPK13 mitogen-activated protein kinase 13 
244p38g(MAPK12)CMGCMAPKp38 MAPK12 mitogen-activated protein kinase 12 
245MAKCMGCRCK MAK male germ cell-associated kinase 
246MOKCMGCRCK RAGE renal tumor antigen 
247ICKCMGCRCK ICK intestinal cell (MAK-like) kinase 
248SRPK1CMGCSRPK SRPK1 SFRS protein kinase 1 
249SRPK2CMGCSRPK SRPK2 SFRS protein kinase 2 
250MSSK1CMGCSRPK SRPK3 SFRS protein kinase 3 
251AurAOtherAur AURKA aurora kinase A 
252AurCOtherAur AURKC aurora kinase C 
253AurBOtherAur AURKB aurora kinase B 
254BUB1OtherBUB BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 
255BUBR1OtherBUB BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) 
256PRPKOtherBud32 TP53RK TP53 regulating kinase 
257CaMKK2OtherCAMKKMeta CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 
258CaMKK1OtherCAMKKMeta CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha 
259CDC7OtherCDC7 CDC7 cell division cycle 7 homolog (S. cerevisiae) 
260HaspinOtherHaspin GSG2 germ cell associated 2 (haspin) 
261IKKaOtherIKK CHUK conserved helix-loop-helix ubiquitous kinase 
262IKKbOtherIKK IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 
263IKKeOtherIKK IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 
264TBK1OtherIKK TBK1 TANK-binding kinase 1 
265IRE1OtherIRE ERN1 endoplasmic reticulum to nucleus signalling 1 
266IRE2OtherIRE ERN2 endoplasmic reticulum to nucleus signalling 2 
267KISOtherKIS UHMK1 U2AF homology motif (UHM) kinase 1 
268MOSOtherMOS MOS v-mos Moloney murine sarcoma viral oncogene homolog 
269AAK1OtherNAKBIKE AAK1 AP2 associated kinase 1 
270BIKEOtherNAKBIKE BMP2K BMP2 inducible kinase 
271GAKOtherNAKGAK GAK cyclin G associated kinase 
272MPSK1OtherNAKMPSK STK16 serine/threonine kinase 16 
273NEK1OtherNEKNEK1 NEK1 NIMA (never in mitosis gene a)-related kinase 1 
274NEK3OtherNEKNEK1 NEK3 NIMA (never in mitosis gene a)-related kinase 3 
275NEK5OtherNEKNEK1 NEK5 NIMA (never in mitosis gene a)-related kinase 5 
276NEK10OtherNEKNEK10 NEK10 NIMA (never in mitosis gene a)- related kinase 10 
277NEK11OtherNEKNEK11 NEK11 NIMA (never in mitosis gene a)- related kinase 11 
278NEK2OtherNEKNEK2 NEK2 NIMA (never in mitosis gene a)-related kinase 2 
279NEK4OtherNEKNEK4 NEK4 NIMA (never in mitosis gene a)-related kinase 4 
280NEK6OtherNEKNEK6 NEK6 NIMA (never in mitosis gene a)-related kinase 6 
281NEK7OtherNEKNEK6 NEK7 NIMA (never in mitosis gene a)-related kinase 7 
282NEK9OtherNEKNEK8 NEK9 NIMA (never in mitosis gene a)- related kinase 9 
283NEK8OtherNEKNEK8 NEK8 NIMA (never in mitosis gene a)- related kinase 8 
284SBKOtherNKF1 SBK1 SH3-binding domain kinase 1 
285SgK069OtherNKF1 LOC646643 similar to protein kinase Bsk146 
287PINK1OtherNKF2 PINK1 PTEN induced putative kinase 1 
288SgK269OtherNKF3 KIAA2002 KIAA2002 protein 
289SgK223OtherNKF3 DKFZp761P0423 homolog of rat pragma of Rnd2 
290CLIK1OtherNKF4 STK35 serine/threonine kinase 35 
291CLIK1LOtherNKF4 PDIK1L PDLIM1 interacting kinase 1 like 
292SgK307OtherNKF5 TEX14 testis expressed sequence 14 
294NRBP1OtherNRBP NRBP1 nuclear receptor binding protein 1 
295NRBP2OtherNRBP NRBP2 nuclear receptor binding protein 2 
296RNAseLOtherOther-Unique RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 
297SgK396OtherOther-Unique STK31 serine/threonine kinase 31 
298SgK196OtherOther-Unique FLJ23356 hypothetical protein FLJ23356 
299GCN2OtherPEKGCN2 EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 
300HRIOtherPEKHRI EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 
301PEKOtherPEKPEK EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 
302PKROtherPEKPKR EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 
303PLK1OtherPLKPLK1 PLK1 polo-like kinase 1 (Drosophila) 
304PLK3OtherPLKPLK2 PLK3 polo-like kinase 3 (Drosophila) 
305PLK2OtherPLKPLK2 PLK2 polo-like kinase 2 (Drosophila) 
306PLK4OtherPLKSAK PLK4 polo-like kinase 4 (Drosophila) 
307SCYL2OtherSCY1 SCYL2 SCY1-like 2 (S. cerevisiae) 
308SCYL3OtherSCY1 SCYL3 SCY1-like 3 (S. cerevisiae) 
309SCYL1OtherSCY1 SCYL1 SCY1-like 1 (S. cerevisiae) 
310SgK071OtherSgK071 C9orf96 chromosome 9 open reading frame 96 
311SgK493OtherSgK493 LOC91461 hypothetical protein BC007901 
312SgK496OtherSgK496 RIPK5 receptor interacting protein kinase 5 
313SlobOtherSlob PXK PX domain containing serine/threonine kinase 
314TBCKOtherTBCK MGC16169 hypothetical protein MGC16169 
315TLK1OtherTLK TLK1 tousled-like kinase 1 
316TLK2OtherTLK TLK2 tousled-like kinase 2 
317PBKOtherTOPK PBK PDZ binding kinase 
318TTKOtherTTK TTK TTK protein kinase 
319FusedOtherULKFused STK36 serine/threonine kinase 36, fused homolog (Drosophila) 
320ULK1OtherULKULK ULK1 unc-51-like kinase 1 (C. elegans) 
321ULK2OtherULKULK ULK2 unc-51-like kinase 2 (C. elegans) 
322ULK3OtherULKULK ULK3 unc-51-like kinase 3 (C. elegans) 
323ULK4OtherULKULK ULK4 unc-51-like kinase 4 (C. elegans) 
324PIK3R4OtherVPS15 PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4, p150 
325Wee1OtherWEE WEE1 WEE1 homolog (S. pombe) 
326MYT1OtherWEE PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 
327Wee1BOtherWEE FLJ40852 hypothetical protein FLJ40852 
328Wnk1OtherWNK WNK1 WNK lysine deficient protein kinase 1 
329Wnk4OtherWNK WNK4 WNK lysine deficient protein kinase 4 
330Wnk3OtherWNK WNK3 WNK lysine deficient protein kinase 3 
331Wnk2OtherWNK WNK2 WNK lysine deficient protein kinase 2 
332HSERRGCRGC GUCY2C guanylate cyclase 2C (heat stable enterotoxin receptor) 
333CYGFRGCRGC GUCY2F guanylate cyclase 2F, retinal 
334CYGDRGCRGC GUCY2D guanylate cyclase 2D, membrane (retina-specific) 
335ANPaRGCRGC NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) 
336ANPbRGCRGC NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) 
337MAP3K5STESTE11ASK MAP3K5 mitogen-activated protein kinase kinase kinase 5 
338MAP3K6STESTE11ASK MAP3K6 mitogen-activated protein kinase kinase kinase 6 
339MAP3K7STESTE11ASK MAP3K15 mitogen-activated protein kinase kinase kinase 15 
340MAP3K1STESTE11MEKK1 MAP3K1 mitogen-activated protein kinase kinase kinase 1 
341MAP3K8STESTE11MEKK15 YSK4 yeast Sps1/Ste20-related kinase 4 (S. cerevisiae) 
342MAP3K3STESTE11MEKK2 MAP3K3 mitogen-activated protein kinase kinase kinase 3 
343MAP3K2STESTE11MEKK2 MAP3K2 mitogen-activated protein kinase kinase kinase 2 
344MAP3K4STESTE11MEKK4 MAP3K4 mitogen-activated protein kinase kinase kinase 4 
345OSR1STESTE20FRAY OXSR1 oxidative-stress responsive 1 
346STLK3STESTE20FRAY STK39 serine threonine kinase 39 (STE20/SPS1 homolog, yeast) 
347GCKSTESTE20KHS MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 
348KHS2STESTE20KHS MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 
349KHS1STESTE20KHS MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 
350HPK1STESTE20KHS MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 
351HGKSTESTE20MSN MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 
352TNIKSTESTE20MSN TNIK TRAF2 and NCK interacting kinase 
353NRKSTESTE20MSN NRK Nik related kinase 
354MINKSTESTE20MSN MINK1 misshapen-like kinase 1 (zebrafish) 
355MST2STESTE20MST STK3 serine/threonine kinase 3 (STE20 homolog, yeast) 
356MST1STESTE20MST STK4 serine/threonine kinase 4 
357MYO3ASTESTE20NinaC MYO3A myosin IIIA 
358MYO3BSTESTE20NinaC MYO3B myosin IIIB 
359PAK1STESTE20PAK(PAKA) PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) 
360PAK2STESTE20PAK(PAKA) PAK2 p21 (CDKN1A)-activated kinase 2 
361PAK3STESTE20PAK(PAKA) PAK3 p21 (CDKN1A)-activated kinase 3 
362PAK4STESTE20PAK(PAKB) PAK4 p21(CDKN1A)-activated kinase 4 
363PAK6STESTE20PAK(PAKB) PAK6 p21(CDKN1A)-activated kinase 6 
364PAK5STESTE20PAK(PAKB) PAK7 p21(CDKN1A)-activated kinase 7 
365LOKSTESTE20SLK STK10 serine/threonine kinase 10 
366SLKSTESTE20SLK SLK STE20-like kinase (yeast) 
367STLK6STESTE20STLK ALS2CR2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 
368STLK5STESTE20STLK LYK5 protein kinase LYK5 
369TAO2STESTE20TAO TAOK2 TAO kinase 2 
370TAO3STESTE20TAO TAOK3 TAO kinase 3 
371TAO1STESTE20TAO TAOK1 TAO kinase 1 
372MST3STESTE20YSK STK24 serine/threonine kinase 24 (STE20 homolog, yeast) 
373YSK1STESTE20YSK STK25 serine/threonine kinase 25 (STE20 homolog, yeast) 
374MST4STESTE20YSK RP6-213H19.1 serine/threonine protein kinase MST4 
375MAP2K1STESTE7MAP2K(MEK1) MAP2K1 mitogen-activated protein kinase kinase 1 
376MAP2K2STESTE7MAP2K(MEK1) MAP2K2 mitogen-activated protein kinase kinase 2 
377MAP2K3STESTE7MAP2K(MEK3) MAP2K3 mitogen-activated protein kinase kinase 3 
378MAP2K6STESTE7MAP2K(MEK3) MAP2K6 mitogen-activated protein kinase kinase 6 
379MAP2K4STESTE7MAP2K(MEK4) MAP2K4 mitogen-activated protein kinase kinase 4 
380MAP2K5STESTE7MAP2K(MEK5) MAP2K5 mitogen-activated protein kinase kinase 5 
381MAP2K7STESTE7MAP2K(MEK7) MAP2K7 mitogen-activated protein kinase kinase 7 
382COTSTESTE-Unique MAP3K8 mitogen-activated protein kinase kinase kinase 8 
383NIKSTESTE-Unique MAP3K14 mitogen-activated protein kinase kinase kinase 14 
384ABL1(Abl)TKAbl ABL1 v-abl Abelson murine leukemia viral oncogene homolog 1 
385ABL2(ARG)TKAbl ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) 
386ACKTKAck TNK2 tyrosine kinase, non-receptor, 2 
387TNK1TKAck TNK1 tyrosine kinase, non-receptor, 1 
388ALKTKALK ALK anaplastic lymphoma kinase (Ki-1) 
389LTKTKALK LTK leukocyte tyrosine kinase 
390AXLTKAxl AXL AXL receptor tyrosine kinase 
391TYRO3TKAxl TYRO3 TYRO3 protein tyrosine kinase 
392MERTKAxl MERTK c-mer proto-oncogene tyrosine kinase 
393CCK4TKCCK4 PTK7 PTK7 protein tyrosine kinase 7 
394CSKTKCsk CSK c-src tyrosine kinase 
395CTKTKCsk MATK megakaryocyte-associated tyrosine kinase 
396DDR1TKDDR DDR1 discoidin domain receptor family, member 1 
397DDR2TKDDR DDR2 discoidin domain receptor family, member 2 
398EGFRTKEGFR EGFR epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) 
399ErbB2TKEGFR ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 
400ErbB3TKEGFR ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 
401ErbB4TKEGFR ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 
402EphA2TKEph EPHA2 EPH receptor A2 
403EphA1TKEph EPHA1 EPH receptor A1 
404EphA3TKEph EPHA3 EPH receptor A3 
405EphA4TKEph EPHA4 EPH receptor A4 
406EphA5TKEph EPHA5 EPH receptor A5 
407EphA7TKEph EPHA7 EPH receptor A7 
408EphA8TKEph EPHA8 EPH receptor A8 
409EphB1TKEph EPHB1 EPH receptor B1 
410EphB2TKEph EPHB2 EPH receptor B2 
411EphB3TKEph EPHB3 EPH receptor B3 
412EphB4TKEph EPHB4 EPH receptor B4 
413EphB6TKEph EPHB6 EPH receptor B6 
414EphA10TKEph EPHA10 EPH receptor A10 
415EphA6TKEph EPHA6 EPH receptor A6 
416PYK2TKFAK PTK2B PTK2B protein tyrosine kinase 2 beta 
417FAKTKFAK PTK2 PTK2 protein tyrosine kinase 2 
418FERTKFer FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) 
419FESTKFer FES feline sarcoma oncogene 
420FGFR1TKFGFR FGFR1 fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) 
421FGFR3TKFGFR FGFR3 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) 
422FGFR2TKFGFR FGFR2 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) 
423FGFR4TKFGFR FGFR4 fibroblast growth factor receptor 4 
424IGF1RTKInsR IGF1R insulin-like growth factor 1 receptor 
425INSRTKInsR INSR insulin receptor 
426IRRTKInsR INSRR insulin receptor-related receptor 
427JAK1TKJAK JAK1 Janus kinase 1 (a protein tyrosine kinase) 
428JAK2TKJAK JAK2 Janus kinase 2 (a protein tyrosine kinase) 
429JAK3TKJAK JAK3 Janus kinase 3 (a protein tyrosine kinase, leukocyte) 
430TYK2TKJAK TYK2 tyrosine kinase 2 
431LMR1TKLmr AATK apoptosis-associated tyrosine kinase 
432LMR2TKLmr LMTK2 lemur tyrosine kinase 2 
433LMR3TKLmr LMTK3 lemur tyrosine kinase 3 
434METTKMet MET met proto-oncogene (hepatocyte growth factor receptor) 
435RONTKMet MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase) 
436MUSKTKMusk MUSK muscle, skeletal, receptor tyrosine kinase 
437FMSTKPDGFR CSF1R colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog 
438FLT3TKPDGFR FLT3 fms-related tyrosine kinase 3 
439KITTKPDGFR KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 
440PDGFRaTKPDGFR PDGFRA platelet-derived growth factor receptor, alpha polypeptide 
441PDGFRbTKPDGFR PDGFRB platelet-derived growth factor receptor, beta polypeptide 
442RETTKRet RET ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) 
443ROR1TKRor ROR1 receptor tyrosine kinase-like orphan receptor 1 
444ROR2TKRor ROR2 receptor tyrosine kinase-like orphan receptor 2 
445RYKTKRyk RYK RYK receptor-like tyrosine kinase 
446ROSTKSev ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian) 
447FRKTKSrcFrk FRK fyn-related kinase 
448FGRTKSrcSrcA FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 
449FYNTKSrcSrcA FYN FYN oncogene related to SRC, FGR, YES 
450SRCTKSrcSrcA SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 
451YESTKSrcSrcA YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 
452BLKTKSrcSrcB BLK B lymphoid tyrosine kinase 
453HCKTKSrcSrcB HCK hemopoietic cell kinase 
454LCKTKSrcSrcB LCK lymphocyte-specific protein tyrosine kinase 
455LYNTKSrcSrcB LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 
456BRKTKSrcSRM PTK6 PTK6 protein tyrosine kinase 6 
457SRMTKSrcSRM SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 
458SYKTKSyk SYK spleen tyrosine kinase 
459ZAP70TKSyk ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 
460BMXTKTec BMX BMX non-receptor tyrosine kinase 
461BTKTKTec BTK Bruton agammaglobulinemia tyrosine kinase 
462ITKTKTec ITK IL2-inducible T-cell kinase 
463TECTKTec TEC tec protein tyrosine kinase 
464TXKTKTec TXK TXK tyrosine kinase 
465TIE2TKTie TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) 
466TIE1TKTie TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 
467SuRTK106TKTK-Unique STYK1 serine/threonine/tyrosine kinase 1 
468TRKATKTrk NTRK1 neurotrophic tyrosine kinase, receptor, type 1 
469TRKBTKTrk NTRK2 neurotrophic tyrosine kinase, receptor, type 2 
470TRKCTKTrk NTRK3 neurotrophic tyrosine kinase, receptor, type 3 
471FLT1TKVEGFR FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 
472FLT4TKVEGFR FLT4 fms-related tyrosine kinase 4 
473KDRTKVEGFR KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 
474IRAK1TKLIRAK IRAK1 interleukin-1 receptor-associated kinase 1 
475IRAK2TKLIRAK IRAK2 interleukin-1 receptor-associated kinase 2 
476IRAK3TKLIRAK IRAK3 interleukin-1 receptor-associated kinase 3 
477IRAK4TKLIRAK IRAK4 interleukin-1 receptor-associated kinase 4 
478LIMK1TKLLISKLIMK LIMK1 LIM domain kinase 1 
479LIMK2TKLLISKLIMK LIMK2 LIM domain kinase 2 
480TESK1TKLLISKTESK TESK1 testis-specific kinase 1 
481TESK2TKLLISKTESK TESK2 testis-specific kinase 2 
482LRRK1TKLLRRK LRRK1 leucine-rich repeat kinase 1 
483LRRK2TKLLRRK LRRK2 leucine-rich repeat kinase 2 
484HH498TKLMLKHH498 TNNI3K TNNI3 interacting kinase 
485ILKTKLMLKILK ILK integrin-linked kinase 
486DLKTKLMLKLZK MAP3K12 mitogen-activated protein kinase kinase kinase 12 
487LZKTKLMLKLZK MAP3K13 mitogen-activated protein kinase kinase kinase 13 
488MLK1TKLMLKMLK MAP3K9 mitogen-activated protein kinase kinase kinase 9 
489MLK2TKLMLKMLK MAP3K10 mitogen-activated protein kinase kinase kinase 10 
490MLK3TKLMLKMLK MAP3K11 mitogen-activated protein kinase kinase kinase 11 
491MLK4TKLMLKMLK KIAA1804 mixed lineage kinase 4 
492TAK1TKLMLKTAK1 MAP3K7 mitogen-activated protein kinase kinase kinase 7 
493ZAKTKLMLKZAK ZAK sterile alpha motif and leucine zipper containing kinase AZK 
494KSR1TKLRAFKSR KSR1 kinase suppressor of ras 1 
495KSR2TKLRAFKSR KSR2 kinase suppressor of ras 2 
496ARAFTKLRAFRAF ARAF v-raf murine sarcoma 3611 viral oncogene homolog 
497BRAFTKLRAFRAF BRAF v-raf murine sarcoma viral oncogene homolog B1 
498RAF1TKLRAFRAF RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 
499RIPK1TKLRIPK RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 
500RIPK2TKLRIPK RIPK2 receptor-interacting serine-threonine kinase 2 
501RIPK3TKLRIPK RIPK3 receptor-interacting serine-threonine kinase 3 
502ANKRD3TKLRIPK RIPK4 receptor-interacting serine-threonine kinase 4 
503SgK288TKLRIPK ANKK1 ankyrin repeat and kinase domain containing 1 
504ALK2TKLSTKRType1 ACVR1 activin A receptor, type I 
505ALK4TKLSTKRType1 ACVR1B activin A receptor, type IB 
506ALK1TKLSTKRType1 ACVRL1 activin A receptor type II-like 1 
507BMPR1ATKLSTKRType1 BMPR1A bone morphogenetic protein receptor, type IA 
508BMPR1BTKLSTKRType1 BMPR1B bone morphogenetic protein receptor, type IB 
509TGFbR1TKLSTKRType1 TGFBR1 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) 
510ALK7TKLSTKRType1 ACVR1C activin A receptor, type IC 
511ACTR2TKLSTKRType2 ACVR2A activin A receptor, type IIA 
512ACTR2BTKLSTKRType2 ACVR2B activin A receptor, type IIB 
513MISR2TKLSTKRType2 AMHR2 anti-Mullerian hormone receptor, type II 
514BMPR2TKLSTKRType2 BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 
515TGFbR2TKLSTKRType2 TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 
516MLKLTKLTKL-Unique MLKL mixed lineage kinase domain-like