Regulatory Network in Protein Phosphorylation
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Kinase: AKT1 v-akt murine thymoma viral oncogene homolog 1

Group: AGC      Family: Akt      

Description: v-akt murine thymoma viral oncogene homolog 1

Gene Symbol: AKT1

Synonyms: AKT, MGC99656, PKB, PRKBA, RAC, RAC-ALPHA

UniprotKB/SwissProt: AKT1_HUMAN (P31749)

Function: General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.

Subcellular Localization: Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1).

Protein Domain:
PDB:1H10

The substrate proteins of kinase AKT1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 2Show
2EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 3Show
3AKT1S1AKTS1_HUMANProline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate). 2Show
4ARANDR_HUMANAndrogen receptor (Dihydrotestosterone receptor) (Nuclear receptorsubfamily 3 group C member 4). 3Show
5ATXN1ATX1_HUMANAtaxin-1 (Spinocerebellar ataxia type 1 protein). 1Show
6BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 5Show
7BIRC4BIRC4_HUMANBaculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3ubiquitin-protein ligase XIAP) (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-likeprotein) (HILP). 1Show
8BRAFBRAF1_HUMANB-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)(p94) (v-Raf murine sarcoma viral oncogene homolog B1). 2Show
9BRCA1BRCA1_HUMANBreast cancer type 1 susceptibility protein (RING finger protein 53). 1Show
10CASP9CASP9_HUMANCaspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 2Show
11CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 3Show
12CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 1Show
13CHEK1CHK1_HUMANSerine/threonine-protein kinase Chk1 (EC 2.7.11.1). 2Show
14CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 1Show
15EDG1