Regulatory Network in Protein Phosphorylation
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Kinase: AKT2 v-akt murine thymoma viral oncogene homolog 2

Group: AGC      Family: Akt      

Description: v-akt murine thymoma viral oncogene homolog 2

Gene Symbol: AKT2

Synonyms: PKBBETA, PRKBB, RAC-BETA

UniprotKB/SwissProt: AKT2_HUMAN (P31751)

Function: General protein kinase capable of phosphorylating several known proteins.

Subcellular Localization:

Protein Domain:
PDB:1GZK

The substrate proteins of kinase AKT2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1AKT1S1AKTS1_HUMANProline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate). 1Show
2BIRC4BIRC4_HUMANBaculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3ubiquitin-protein ligase XIAP) (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-likeprotein) (HILP). 2Show
3ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 2Show
4VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 1Show
5FOXO4FOXO4_HUMANForkhead box protein O4 (Fork head domain transcription factor AFX1). 1Show
6CHUKIKKA_HUMANInhibitor of nuclear factor kappa-B kinase subunit alpha(EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A)(IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinasealpha) (NFKBIKA). 1Show
7MAP3K5M3K5_HUMANMitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25)(MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1). 1Show



The substrate proteins of kinase family Akt

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 3Show
2EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 3Show
3ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 1Show
4AHNAKAHNK_HUMANNeuroblast differentiation-associated protein AHNAK (Desmoyokin). 1Show
5AKT1S1AKTS1_HUMANProline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate). 3Show
6ARANDR_HUMANAndrogen receptor (Dihydrotestosterone receptor) (Nuclear receptorsubfamily 3 group C member 4). 5Show
7C20orf74AS250_HUMAN250 kDa substrate of Akt (AS250). 3Show
8ATXN1ATX1_HUMANAtaxin-1 (Spinocerebellar ataxia type 1 protein). 2Show
9BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 9Show
10BIRC4BIRC4_HUMANBaculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3ubiquitin-protein ligase XIAP) (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-likeprotein) (HILP). 4Show
11BRAFBRAF1_HUMANB-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)(p94) (v-Raf murine sarcoma viral oncogene homolog B1). 4Show
12BRCA1BRCA1_HUMANBreast cancer type 1 susceptibility protein (RING finger protein 53). 2Show
13CASP9CASP9_HUMANCaspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 3Show
14CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 5Show
15CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 3Show
16CENTB1CENB1_HUMANCentaurin-beta-1 (Cnt-b1) (ARFGAP with coiled-coil, ANK repeat and PHdomain-containing protein 1) (ACAP1). 2Show
17CHEK1CHK1_HUMANSerine/threonine-protein kinase Chk1 (EC 2.7.11.1). 3Show
18CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 2Show
19EDG1EDG1_HUMANSphingosine 1-phosphate receptor Edg-1 (Sphingosine 1-phosphatereceptor 1) (S1P1). 3Show
20EP300EP300_HUMANHistone acetyltransferase p300 (EC 2.3.1.48) (E1A-associated proteinp300). 2Show
21ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 3Show
22EZH2EZH2_HUMANEnhancer of zeste homolog 2 (ENX-1) (Lysine N-methyltransferase 6). 1Show
23VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 1Show
24PFKFB2F262_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru-2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase(EC 3.1.3.46)]. 4Show
25FANCAFANCA_HUMANFanconi anemia group A protein (Protein FACA). 2Show
26FOXO1FOXO1_HUMANForkhead box protein O1 (Forkhead box protein O1A) (Forkhead inrhabdomyosarcoma). 11Show
27FOXO3FOXO3_HUMANForkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21protein). 8Show
28FOXO4FOXO4_HUMANForkhead box protein O4 (Fork head domain transcription factor AFX1). 12Show
29FRAP1FRAP_HUMANFKBP12-rapamycin complex-associated protein (FK506-binding protein 12-rapamycin complex-associated protein 1) (Rapamycin target protein)(RAPT1) (Mammalian target of rapamycin) (mTOR). 4Show
30PIP5K3FYV1_HUMANFYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1-phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3-phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve)(p235). 1Show
31GAB2GAB2_HUMANGRB2-associated-binding protein 2 (Growth factor receptor boundprotein 2-associated protein 2) (GRB2-associated binder 2) (pp100). 3Show
32GATA1GATA1_HUMANErythroid transcription factor (GATA-binding factor 1) (GATA-1)(Eryf1) (GF-1) (NF-E1 DNA-binding protein). 2Show
33CCDC88AGRDN_HUMANGirdin (Girders of actin filament) (Coiled-coil domain-containingprotein 88A) (Akt phosphorylation enhancer) (APE) (Hook-relatedprotein 1) (HkRP1) (G alpha-interacting vesicle-associated protein)(GIV). 1Show
34GSK3AGSK3A_HUMANGlycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha). 1Show
35GSK3BGSK3B_HUMANGlycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta). 2Show
36HDHD_HUMANHuntingtin (Huntington disease protein) (HD protein). 2Show
37HJURPHJURP_HUMANHolliday junction recognition protein (14-3-3-associated AKTsubstrate) (Fetal liver-expressing gene 1 protein) (Up-regulated inlung cancer 9). 1Show
38HMOX1HMOX1_HUMANHeme oxygenase 1 (EC 1.14.99.3) (HO-1). 1Show
39HSPB1HSPB1_HUMANHeat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27)(Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDaprotein) (28 kDa heat shock protein). 1Show
40CHUKIKKA_HUMANInhibitor of nuclear factor kappa-B kinase subunit alpha(EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A)(IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinasealpha) (NFKBIKA). 4Show
41IRAK1IRAK1_HUMANInterleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1). 3Show
42ITGB3ITB3_HUMANIntegrin beta-3 precursor (Platelet membrane glycoprotein IIIa)(GPIIIa) (CD61 antigen). 2Show
43PRKAR2BKAP3_HUMANcAMP-dependent protein kinase type II-beta regulatory subunit. 1Show
44MAP3K11M3K11_HUMANMitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25)(Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase). 2Show
45MAP3K5M3K5_HUMANMitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25)(MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1). 2Show
46MAP3K8M3K8_HUMANMitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COTproto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osakathyroid oncogene) (Tumor progression locus 2) (TPL-2). 3Show
47MDM2MDM2_HUMANE3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (p53-binding proteinMdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2). 5Show
48MAP2K4MP2K4_HUMANDual specificity mitogen-activated protein kinase kinase 4(EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-JunN-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1). 2Show
49NCF1NCF1_HUMANNeutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDaautosomal chronic granulomatous disease protein) (Nox organizer 2)(Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A). 2Show
50NOS3NOS3_HUMANNitric oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS typeIII) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS). 4Show
51NR4A1NR4A1_HUMANNuclear receptor subfamily 4 group A member 1 (Orphan nuclear receptorHMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59). 2Show
52NUAK1NUAK1_HUMANNUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related proteinkinase 5). 2Show
53PDCD4PDCD4_HUMANProgrammed cell death protein 4 (Nuclear antigen H731-like)(Neoplastic transformation inhibitor protein) (Protein 197/15a). 2Show
54PDE3BPDE3B_HUMANcGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (CyclicGMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1). 3Show
55PEA15PEA15_HUMANAstrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes)(PED). 2Show
56PTENPTEN_HUMANPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1). 4Show
57PTPN1PTN1_HUMANTyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1B) (PTP-1B). 3Show
58RAC1RAC1_HUMANRas-related C3 botulinum toxin substrate 1 precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein). 2Show
59RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 2Show
60DLC1RHG07_HUMANRho GTPase-activating protein 7 (Rho-type GTPase-activating protein 7)(Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-relatedlipid transfer protein 12) (StARD12) (START domain-containing protein12). 3Show
61MST1RRON_HUMANMacrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSPreceptor) (p185-Ron) (CD136 antigen) (CDw136) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulatingprotein receptor beta chain]. 1Show
62SH2B2SH2B2_HUMANSH2B adapter protein 2 (SH2 and PH domain-containing adapter proteinAPS) (Adapter protein with pleckstrin homology and Src homology 2domains). 1Show
63TBC1D4TBCD4_HUMANTBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160). 7Show
64TERTTERT_HUMANTelomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalyticsubunit) (HEST2) (Telomerase-associated protein 2) (TP2). 4Show
65ZFP36L1TISB_HUMANButyrate response factor 1 (Protein TIS11B) (EGF-response factor 1)(ERF-1). 1Show
66TSC2TSC2_HUMANTuberin (Tuberous sclerosis 2 protein). 5Show
67WEE1WEE1_HUMANWee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). 1Show
68WNK1WNK1_HUMANSerine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinasewith no lysine 1) (Protein kinase, lysine-deficient 1) (Kinasedeficient protein) (Erythrocyte 65 kDa protein) (p65). 1Show
69YAP1YAP1_HUMAN65 kDa Yes-associated protein (YAP65). 2Show
70YBX1YBOX1_HUMANNuclease-sensitive element-binding protein 1 (Y-box-binding protein 1)(Y-box transcription factor) (YB-1) (CCAAT-binding transcriptionfactor I subunit A) (CBF-A) (Enhancer factor I subunit A) (EFI-A)(DNA-binding protein B) (DBPB). 2Show