|Group: AGC Family: DMPK Subfamily: CRIK|
Description: citron (rho-interacting, serine/threonine kinase 21)
Gene Symbol: CIT
Synonyms: CRIK, KIAA0949, STK21
UniprotKB/SwissProt: CTRO_HUMAN (O14578)
Function: Required for KIF14 localization to the central spindle and midbody. May play a role in cytokinesis. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system (By similarity).
Subcellular Localization: Cytoplasm (By similarity).