Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: CRIK citron (rho-interacting, serine/threonine kinase 21)

Group: AGC      Family: DMPK      Subfamily: CRIK

Description: citron (rho-interacting, serine/threonine kinase 21)

Gene Symbol: CIT

Synonyms: CRIK, KIAA0949, STK21

UniprotKB/SwissProt: CTRO_HUMAN (O14578)

Function: Required for KIF14 localization to the central spindle and midbody. May play a role in cytokinesis. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system (By similarity).

Subcellular Localization: Cytoplasm (By similarity).

Protein Domain: