|Group: AGC Family: DMPK Subfamily: GEK|
Description: CDC42 binding protein kinase alpha (DMPK-like)
Gene Symbol: CDC42BPA
Synonyms: DKFZp686L1738, DKFZp686P1738, FLJ23347, KIAA0451, MRCK, MRCKA, PK428
UniprotKB/SwissProt: MRCKA_HUMAN (Q5VT25)
Function: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.
Subcellular Localization: Cytoplasm (By similarity). Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity).