Regulatory Network in Protein Phosphorylation
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Kinase: MRCKa CDC42 binding protein kinase alpha (DMPK-like)

Group: AGC      Family: DMPK      Subfamily: GEK

Description: CDC42 binding protein kinase alpha (DMPK-like)

Gene Symbol: CDC42BPA

Synonyms: DKFZp686L1738, DKFZp686P1738, FLJ23347, KIAA0451, MRCK, MRCKA, PK428

UniprotKB/SwissProt: MRCKA_HUMAN (Q5VT25)

Function: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.

Subcellular Localization: Cytoplasm (By similarity). Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity).

Protein Domain:

The substrate proteins of kinase MRCKa

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1LIMK1LIMK1_HUMANLIM domain kinase 1 (EC 2.7.11.1) (LIMK-1). 2Show
2LIMK2LIMK2_HUMANLIM domain kinase 2 (EC 2.7.11.1) (LIMK-2). 3Show
3PPP1R12AMYPT1_HUMANProtein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Proteinphosphatase myosin-binding subunit). 1Show