Regulatory Network in Protein Phosphorylation
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Kinase: MRCKb CDC42 binding protein kinase beta (DMPK-like)

Group: AGC      Family: DMPK      Subfamily: GEK

Description: CDC42 binding protein kinase beta (DMPK-like)

Gene Symbol: CDC42BPB

Synonyms: KIAA1124, MRCKB

UniprotKB/SwissProt: MRCKB_HUMAN (Q9Y5S2)

Function: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).

Subcellular Localization: Cytoplasm (By similarity). Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity).

Protein Domain: