Regulatory Network in Protein Phosphorylation
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Kinase: ROCK1 Rho-associated, coiled-coil containing protein kinase 1

Group: AGC      Family: DMPK      Subfamily: ROCK

Description: Rho-associated, coiled-coil containing protein kinase 1

Gene Symbol: ROCK1

Synonyms: MGC131603, MGC43611, P160ROCK

UniprotKB/SwissProt: ROCK1_HUMAN (Q13464)

Function: Protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Necessary for apoptotic membrane blebbing. Plays a role in smooth muscle contraction. Required for centromere positioning and centromere- dependent exit from mitosis (By similarity).

Subcellular Localization: Cytoplasm. Centrosome, centriole (By similarity). Golgi apparatus membrane; Peripheral membrane protein. Note=Associated with the mother centriole and an intercentriolar linker (By similarity). A small proportion is associated with Golgi membranes.

Protein Domain:
PDB:1S1C

The substrate proteins of kinase ROCK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ADD1ADDA_HUMANAlpha-adducin (Erythrocyte adducin subunit alpha). 7Show
2DESDESM_HUMANDesmin. 3Show
3DPYSL2DPYL2_HUMANDihydropyrimidinase-related protein 2 (DRP-2) (Collapsin responsemediator protein 2) (CRMP-2) (N2A3). 1Show
4VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 2Show
5PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 1Show
6GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 7Show
7LIMK1LIMK1_HUMANLIM domain kinase 1 (EC 2.7.11.1) (LIMK-1). 2Show
8LIMK2LIMK2_HUMANLIM domain kinase 2 (EC 2.7.11.1) (LIMK-2). 2Show
9MRLC2MLRM_HUMANMyosin regulatory light chain 2, nonsarcomeric (Myosin RLC). 2Show
10MSNMOES_HUMANMoesin (Membrane-organizing extension spike protein). 1Show
11PPP1R12AMYPT1_HUMANProtein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Proteinphosphatase myosin-binding subunit). 5Show
12PTENPTEN_HUMANPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1). 2Show
13RDXRADI_HUMANRadixin. 2Show
14ARHGAP24RHG24_HUMANRho GTPase-activating protein 24 (Rho-type GTPase-activating protein24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa)(RC-GAP72) (Sarcoma antigen NY-SAR-88). 11Show
15VASPVASP_HUMANVasodilator-stimulated phosphoprotein (VASP). 1Show
16VIMVIME_HUMANVimentin. 2Show



The substrate proteins of kinase family ROCK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ADD1ADDA_HUMANAlpha-adducin (Erythrocyte adducin subunit alpha). 8Show
2DESDESM_HUMANDesmin. 6Show
3DPYSL2DPYL2_HUMANDihydropyrimidinase-related protein 2 (DRP-2) (Collapsin responsemediator protein 2) (CRMP-2) (N2A3). 2Show
4VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 2Show
5PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 1Show
6GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 8Show
7LIMK1LIMK1_HUMANLIM domain kinase 1 (EC 2.7.11.1) (LIMK-1). 3Show
8LIMK2LIMK2_HUMANLIM domain kinase 2 (EC 2.7.11.1) (LIMK-2). 3Show
9MRLC2MLRM_HUMANMyosin regulatory light chain 2, nonsarcomeric (Myosin RLC). 2Show
10MSNMOES_HUMANMoesin (Membrane-organizing extension spike protein). 2Show
11PPP1R12AMYPT1_HUMANProtein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Proteinphosphatase myosin-binding subunit). 6Show
12PTENPTEN_HUMANPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1). 2Show
13RDXRADI_HUMANRadixin. 4Show
14ARHGAP24RHG24_HUMANRho GTPase-activating protein 24 (Rho-type GTPase-activating protein24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa)(RC-GAP72) (Sarcoma antigen NY-SAR-88). 11Show
15VASPVASP_HUMANVasodilator-stimulated phosphoprotein (VASP). 1Show
16VIMVIME_HUMANVimentin. 3Show