Regulatory Network in Protein Phosphorylation
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Kinase: ROCK2 Rho-associated, coiled-coil containing protein kinase 2

Group: AGC      Family: DMPK      Subfamily: ROCK

Description: Rho-associated, coiled-coil containing protein kinase 2

Gene Symbol: ROCK2

Synonyms: KIAA0619

UniprotKB/SwissProt: ROCK2_HUMAN (O75116)

Function: Protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton. Promotes formation of stress fibers and of focal adhesion complexes. Plays a role in smooth muscle contraction (By similarity).

Subcellular Localization: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane (By similarity).

Protein Domain:

The substrate proteins of kinase ROCK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1DPYSL2DPYL2_HUMANDihydropyrimidinase-related protein 2 (DRP-2) (Collapsin responsemediator protein 2) (CRMP-2) (N2A3). 1Show
2PPP1R12AMYPT1_HUMANProtein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Proteinphosphatase myosin-binding subunit). 1Show



The substrate proteins of kinase family ROCK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ADD1ADDA_HUMANAlpha-adducin (Erythrocyte adducin subunit alpha). 8Show
2DESDESM_HUMANDesmin. 6Show
3DPYSL2DPYL2_HUMANDihydropyrimidinase-related protein 2 (DRP-2) (Collapsin responsemediator protein 2) (CRMP-2) (N2A3). 2Show
4VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 2Show
5PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 1Show
6GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 8Show
7LIMK1LIMK1_HUMANLIM domain kinase 1 (EC 2.7.11.1) (LIMK-1). 3Show
8LIMK2LIMK2_HUMANLIM domain kinase 2 (EC 2.7.11.1) (LIMK-2). 3Show
9MRLC2MLRM_HUMANMyosin regulatory light chain 2, nonsarcomeric (Myosin RLC). 2Show
10MSNMOES_HUMANMoesin (Membrane-organizing extension spike protein). 2Show
11PPP1R12AMYPT1_HUMANProtein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Proteinphosphatase myosin-binding subunit). 6Show
12PTENPTEN_HUMANPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1). 2Show
13RDXRADI_HUMANRadixin. 4Show
14ARHGAP24RHG24_HUMANRho GTPase-activating protein 24 (Rho-type GTPase-activating protein24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa)(RC-GAP72) (Sarcoma antigen NY-SAR-88). 11Show
15VASPVASP_HUMANVasodilator-stimulated phosphoprotein (VASP). 1Show
16VIMVIME_HUMANVimentin. 3Show