Regulatory Network in Protein Phosphorylation
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Kinase: BARK2 adrenergic, beta, receptor kinase 2

Group: AGC      Family: GRK      Subfamily: BARK

Description: adrenergic, beta, receptor kinase 2

Gene Symbol: ADRBK2

Synonyms: BARK2, GRK3

UniprotKB/SwissProt: ARBK2_HUMAN (P35626)

Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase BARK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1BDKRB2BKRB2_HUMANB2 bradykinin receptor (BK-2 receptor) (B2R). 3Show
2CCR5CCR5_HUMANC-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5)(HIV-1 fusion coreceptor) (CHEMR13) (CD195 antigen). 7Show



The substrate proteins of kinase family BARK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ADRA2AADA2A_HUMANAlpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtypeC10). 4Show
2ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 6Show
3BDKRB2BKRB2_HUMANB2 bradykinin receptor (BK-2 receptor) (B2R). 6Show
4CCR5CCR5_HUMANC-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5)(HIV-1 fusion coreceptor) (CHEMR13) (CD195 antigen). 7Show
5PDE6GCNRG_HUMANRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterasesubunit gamma (EC 3.1.4.17) (GMP-PDE gamma). 2Show
6VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 1Show
7FPR1FPR1_HUMANfMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor)(FPR) (N-formylpeptide chemoattractant receptor). 16Show
8HRH1HRH1_HUMANHistamine H1 receptor. 1Show
9MC4RMC4R_HUMANMelanocortin receptor 4 (MC4-R). 5Show
10OPRD1OPRD_HUMANDelta-type opioid receptor (DOR-1). 6Show
11PDGFRBPGFRB_HUMANBeta-type platelet-derived growth factor receptor precursor(EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen). 1Show
12RPLP2RLA2_HUMAN60S acidic ribosomal protein P2 (Renal carcinoma antigen NY-REN-44). 4Show
13SNCASYUA_HUMANAlpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 componentof amyloid precursor) (NACP). 3Show
14SNCBSYUB_HUMANBeta-synuclein. 1Show
15SNCGSYUG_HUMANGamma-synuclein (Persyn) (Breast cancer-specific gene 1 protein)(Synoretin) (SR). 1Show
16TUBB3TBB3_HUMANTubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4). 3Show