|Group: AGC Family: NDR |
Description: LATS, large tumor suppressor, homolog 1 (Drosophila)
Gene Symbol: LATS1
Synonyms: WARTS, wts
UniprotKB/SwissProt: LATS1_HUMAN (O95835)
Function: Tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDC2 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Subcellular Localization: Centrosome. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.