Regulatory Network in Protein Phosphorylation
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Kinase: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)

Group: AGC      Family: NDR      

Description: LATS, large tumor suppressor, homolog 1 (Drosophila)

Gene Symbol: LATS1

Synonyms: WARTS, wts

UniprotKB/SwissProt: LATS1_HUMAN (O95835)

Function: Tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDC2 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.

Subcellular Localization: Centrosome. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.

Protein Domain:

The substrate proteins of kinase family NDR

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1STK38LST38L_HUMANSerine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 proteinkinase) (Nuclear Dbf2-related kinase 2). 1Show
2STK38STK38_HUMANSerine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase)(Nuclear Dbf2-related kinase 1). 4Show