|Group: AGC Family: NDR |
Description: LATS, large tumor suppressor, homolog 2 (Drosophila)
Gene Symbol: LATS2
UniprotKB/SwissProt: LATS2_HUMAN (Q9NRM7)
Function: Tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down- regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.
Subcellular Localization: Centrosome. Cytoplasm. Note=Co-localizes with STK6 at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis.