Regulatory Network in Protein Phosphorylation
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Kinase: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)

Group: AGC      Family: NDR      

Description: LATS, large tumor suppressor, homolog 2 (Drosophila)

Gene Symbol: LATS2

Synonyms: FLJ13161

UniprotKB/SwissProt: LATS2_HUMAN (Q9NRM7)

Function: Tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down- regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.

Subcellular Localization: Centrosome. Cytoplasm. Note=Co-localizes with STK6 at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis.

Protein Domain:

The substrate proteins of kinase family NDR

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1STK38LST38L_HUMANSerine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 proteinkinase) (Nuclear Dbf2-related kinase 2). 1Show
2STK38STK38_HUMANSerine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase)(Nuclear Dbf2-related kinase 1). 4Show