|Group: AGC Family: PDK1 |
Description: 3-phosphoinositide dependent protein kinase-1
Gene Symbol: PDPK1
Synonyms: MGC20087, MGC35290, PDK1, PRO0461, PkB-like, PkB-like 1
UniprotKB/SwissProt: PDPK1_HUMAN (O15530)
Function: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.
Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.