Regulatory Network in Protein Phosphorylation
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Kinase: PDK1 3-phosphoinositide dependent protein kinase-1

Group: AGC      Family: PDK1      

Description: 3-phosphoinositide dependent protein kinase-1

Gene Symbol: PDPK1

Synonyms: MGC20087, MGC35290, PDK1, PRO0461, PkB-like, PkB-like 1

UniprotKB/SwissProt: PDPK1_HUMAN (O15530)

Function: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.

Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.

Protein Domain:
PDB:1H1W

The substrate proteins of kinase PDK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1AKT1AKT1_HUMANRAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha)(Protein kinase B) (PKB) (C-AKT). 5Show
2AKT2AKT2_HUMANRAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta)(Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta). 6Show
3AKT3AKT3_HUMANRAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma)(Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2). 3Show
4ITGB3ITB3_HUMANIntegrin beta-3 precursor (Platelet membrane glycoprotein IIIa)(GPIIIa) (CD61 antigen). 4Show
5PRKCDKPCD_HUMANProtein kinase C delta type (EC 2.7.11.13) (nPKC-delta). 3Show
6PRKCEKPCE_HUMANProtein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon). 3Show
7PRKCZKPCZ_HUMANProtein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta). 3Show
8RPS6KA1KS6A1_HUMANRibosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1)(RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a)(MAPKAPK1A). 2Show
9RPS6KB1KS6B1_HUMANRibosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha). 6Show
10RPS6KB2KS6B2_HUMANRibosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDaribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinasebeta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14beta). 3Show
11MAP3K5M3K5_HUMANMitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25)(MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1). 1Show
12MAP2K1MP2K1_HUMANDual specificity mitogen-activated protein kinase kinase 1(EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)(MAPK/ERK kinase 1) (MEK1). 1Show
13MAP2K2MP2K2_HUMANDual specificity mitogen-activated protein kinase kinase 2(EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2)(MAPK/ERK kinase 2) (MEK2). 1Show
14PAK1PAK1_HUMANSerine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activatedkinase 1) (PAK-1) (p65-PAK) (Alpha-PAK). 2Show
15PDPK1PDPK1_HUMAN3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1). 8Show
16PKN1PKN1_HUMANSerine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C-like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-likePKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha). 3Show
17PKN2PKN2_HUMANSerine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2). 3Show
18SGK1SGK1_HUMANSerine/threonine-protein kinase Sgk1 (EC 2.7.11.1)(Serum/glucocorticoid-regulated kinase 1). 5Show
19SGK2SGK2_HUMANSerine/threonine-protein kinase Sgk2 (EC 2.7.11.1)(Serum/glucocorticoid-regulated kinase 2). 4Show
20SGK3SGK3_HUMANSerine/threonine-protein kinase Sgk3 (EC 2.7.11.1)(Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like). 4Show
21MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 16Show
22ZBTB16ZBT16_HUMANZinc finger and BTB domain-containing protein 16 (Zinc finger proteinPLZF) (Promyelocytic leukemia zinc finger protein) (Zinc fingerprotein 145). 6Show



The substrate proteins of kinase family PDK1

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1AKT1AKT1_HUMANRAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha)(Protein kinase B) (PKB) (C-AKT). 5Show
2AKT2AKT2_HUMANRAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta)(Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta). 6Show
3AKT3AKT3_HUMANRAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma)(Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2). 3Show
4ITGB3ITB3_HUMANIntegrin beta-3 precursor (Platelet membrane glycoprotein IIIa)(GPIIIa) (CD61 antigen). 4Show
5PRKCDKPCD_HUMANProtein kinase C delta type (EC 2.7.11.13) (nPKC-delta). 3Show
6PRKCEKPCE_HUMANProtein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon). 3Show
7PRKCZKPCZ_HUMANProtein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta). 3Show
8RPS6KA1KS6A1_HUMANRibosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1)(RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a)(MAPKAPK1A). 2Show
9RPS6KB1KS6B1_HUMANRibosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha). 6Show
10RPS6KB2KS6B2_HUMANRibosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDaribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinasebeta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14beta). 3Show
11MAP3K5M3K5_HUMANMitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25)(MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1). 1Show
12MAP2K1MP2K1_HUMANDual specificity mitogen-activated protein kinase kinase 1(EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)(MAPK/ERK kinase 1) (MEK1). 1Show
13MAP2K2MP2K2_HUMANDual specificity mitogen-activated protein kinase kinase 2(EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2)(MAPK/ERK kinase 2) (MEK2). 1Show
14PAK1PAK1_HUMANSerine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activatedkinase 1) (PAK-1) (p65-PAK) (Alpha-PAK). 2Show
15PDPK1PDPK1_HUMAN3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1). 8Show
16PKN1PKN1_HUMANSerine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C-like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-likePKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha). 3Show
17PKN2PKN2_HUMANSerine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2). 3Show
18SGK1SGK1_HUMANSerine/threonine-protein kinase Sgk1 (EC 2.7.11.1)(Serum/glucocorticoid-regulated kinase 1). 5Show
19SGK2SGK2_HUMANSerine/threonine-protein kinase Sgk2 (EC 2.7.11.1)(Serum/glucocorticoid-regulated kinase 2). 4Show
20SGK3SGK3_HUMANSerine/threonine-protein kinase Sgk3 (EC 2.7.11.1)(Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like). 4Show
21MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 16Show
22ZBTB16ZBT16_HUMANZinc finger and BTB domain-containing protein 16 (Zinc finger proteinPLZF) (Promyelocytic leukemia zinc finger protein) (Zinc fingerprotein 145). 6Show