Regulatory Network in Protein Phosphorylation
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Kinase: PDK1 3-phosphoinositide dependent protein kinase-1

Group: AGC      Family: PDK1      

Description: 3-phosphoinositide dependent protein kinase-1

Gene Symbol: PDPK1

Synonyms: MGC20087, MGC35290, PDK1, PRO0461, PkB-like, PkB-like 1

UniprotKB/SwissProt: PDPK1_HUMAN (O15530)

Function: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.

Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.

Protein Domain:
PDB:1H1W