Regulatory Network in Protein Phosphorylation
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Kinase: PKACb protein kinase, cAMP-dependent, catalytic, beta

Group: AGC      Family: PKA      

Description: protein kinase, cAMP-dependent, catalytic, beta

Gene Symbol: PRKACB

Synonyms: DKFZp781I2452, MGC41879, MGC9320, PKACB

UniprotKB/SwissProt: KAPCB_HUMAN (P22694)

Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.

Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).

Protein Domain:

The substrate proteins of kinase PKACb

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1NGFRTNR16_HUMANTumor necrosis factor receptor superfamily member 16 precursor (Low-affinity nerve growth factor receptor) (NGF receptor) (Gp80-LNGFR)(p75 ICD) (Low affinity neurotrophin receptor p75NTR) (CD271 antigen). 1Show

The substrate proteins of kinase family PKA

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 3Show
2HLA-A1A01_HUMANHLA class I histocompatibility antigen, A-1 alpha chain precursor (MHCclass I antigen A*1). 3Show
3ABCA1ABCA1_HUMANATP-binding cassette sub-family A member 1 (ATP-binding cassettetransporter 1) (ATP-binding cassette 1) (ABC-1) (Cholesterol effluxregulatory protein). 6Show
4ACACAACACA_HUMANAcetyl-CoA carboxylase 1 (EC (ACC-alpha) [Includes: Biotincarboxylase (EC]. 7Show
5ACACBACACB_HUMANAcetyl-CoA carboxylase 2 (EC (ACC-beta) [Includes: Biotincarboxylase (EC]. 1Show
6ACCN2ACCN2_HUMANAmiloride-sensitive cation channel 2, neuronal (Acid-sensing ionchannel 1) (ASIC1) (Brain sodium channel 2) (BNaC2). 3Show
7ACLYACLY_HUMANATP-citrate synthase (EC (ATP-citrate (pro-S-)-lyase)(Citrate cleavage enzyme). 3Show
8ADRA1AADA1A_HUMANAlpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha 1A-adrenoreceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergicreceptor 1c). 1Show
9ADD1ADDA_HUMANAlpha-adducin (Erythrocyte adducin subunit alpha). 11Show
10ADD2ADDB_HUMANBeta-adducin (Erythrocyte adducin subunit beta). 7Show
11ADRB1ADRB1_HUMANBeta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1adrenoreceptor). 2Show
12ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 7Show
13AKAP13AKP13_HUMANA-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoringprotein 13) (Breast cancer nuclear receptor-binding auxiliary protein)(Human thyroid-anchoring protein 31) (Guanine nucleotide exchangefactor Lbc) (AKAP-Lbc) (LBC oncogene) (P47) (Lymphoid blast crisisoncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor). 2Show
14NPR1ANPRA_HUMANAtrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A)(Guanylate cyclase) (EC (NPR-A) (Atrial natriuretic peptideA-type receptor). 1Show
15ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 1Show
16TFAP2AAP2A_HUMANTranscription factor AP-2 alpha (AP2-alpha) (Activating enhancer-binding protein 2 alpha) (AP-2 transcription factor) (Activatorprotein 2) (AP-2). 1Show
17TFAP2BAP2B_HUMANTranscription factor AP-2 beta (AP2-beta) (Activating enhancer-bindingprotein 2 beta). 1Show
18TFAP2CAP2C_HUMANTranscription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1). 1Show
19TFAP2DAP2D_HUMANTranscription factor AP-2 delta (AP2-delta) (Activating enhancer-binding protein 2 delta) (Transcription factor AP-2 beta-like 1). 1Show
20TFAP2EAP2E_HUMANTranscription factor AP-2 epsilon (AP2-epsilon) (Activating enhancer-binding protein 2 epsilon). 1Show
21APCAPC_HUMANAdenomatous polyposis coli protein (Protein APC). 2Show
22AQP2AQP2_HUMANAquaporin-2 (AQP-2) (Aquaporin-CD) (AQP-CD) (Water channel protein forrenal collecting duct) (ADH water channel) (Collecting duct waterchannel protein) (WCH-CD). 2Show
23ADRBK1ARBK1_HUMANBeta-adrenergic receptor kinase 1 (EC (Beta-ARK-1) (G-protein coupled receptor kinase 2). 2Show
24ARPP19ARP19_HUMANcAMP-regulated phosphoprotein 19 (ARPP-19). 1Show
25ATP12AAT12A_HUMANPotassium-transporting ATPase alpha chain 2 (EC (Protonpump) (Non-gastric H(+)/K(+) ATPase subunit alpha). 1Show
26ATP1A1AT1A1_HUMANSodium/potassium-transporting ATPase subunit alpha-1 precursor(EC (Sodium pump subunit alpha-1) (Na(+)/K(+) ATPase alpha-1subunit). 1Show
27ATP1A2AT1A2_HUMANSodium/potassium-transporting ATPase subunit alpha-2 precursor(EC (Sodium pump subunit alpha-2) (Na(+)/K(+) ATPase alpha-2subunit). 1Show
28ATP1A3AT1A3_HUMANSodium/potassium-transporting ATPase subunit alpha-3 (EC pump subunit alpha-3) (Na(+)/K(+) ATPase alpha-3 subunit)(Na(+)/K(+) ATPase alpha(III) subunit). 1Show
29ATP1A4AT1A4_HUMANSodium/potassium-transporting ATPase subunit alpha-4 (EC pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). 1Show
30ATP2B1AT2B1_HUMANPlasma membrane calcium-transporting ATPase 1 (EC (PMCA1)(Plasma membrane calcium pump isoform 1) (Plasma membrane calciumATPase isoform 1). 3Show
31ATP2B2AT2B2_HUMANPlasma membrane calcium-transporting ATPase 2 (EC (PMCA2)(Plasma membrane calcium pump isoform 2) (Plasma membrane calciumATPase isoform 2). 1Show
32ATF1ATF1_HUMANCyclic AMP-dependent transcription factor ATF-1 (Activatingtranscription factor 1) (TREB36 protein). 1Show
33ATF2ATF2_HUMANCyclic AMP-dependent transcription factor ATF-2 (Activatingtranscription factor 2) (cAMP response element-binding protein CRE-BP1) (HB16). 1Show
34ATP4AATP4A_HUMANPotassium-transporting ATPase alpha chain 1 (EC (Protonpump) (Gastric H(+)/K(+) ATPase subunit alpha). 1Show
35BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 6Show
36BAG2BAG2_HUMANBAG family molecular chaperone regulator 2 (Bcl-2-associatedathanogene 2) (BAG-2). 2Show
37BFSP1BFSP1_HUMANFilensin (Beaded filament structural protein 1) (Lens fiber cellbeaded-filament structural protein CP 115) (CP115) (Lens intermediatefilament-like heavy) (LIFL-H). 1Show
38BRAFBRAF1_HUMANB-Raf proto-oncogene serine/threonine-protein kinase (EC (v-Raf murine sarcoma viral oncogene homolog B1). 2Show
39CIITAC2TA_HUMANMHC class II transactivator (CIITA). 4Show
40CACNA1ACAC1A_HUMANVoltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type,alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI). 1Show
41CACNA1BCAC1B_HUMANVoltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type,alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII). 1Show
42CACNA1CCAC1C_HUMANVoltage-dependent L-type calcium channel subunit alpha-1C (Voltage-gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type,alpha-1 polypeptide, isoform 1, cardiac muscle). 6Show
43CACNA1DCAC1D_HUMANVoltage-dependent L-type calcium channel subunit alpha-1D (Voltage-gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type,alpha-1 polypeptide, isoform 2). 1Show
44CACNA1ECAC1E_HUMANVoltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type,alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII). 1Show
45CACNA1FCAC1F_HUMANVoltage-dependent L-type calcium channel subunit alpha-1F (Voltage-gated calcium channel subunit alpha Cav1.4). 1Show
46CACNA1SCAC1S_HUMANVoltage-dependent L-type calcium channel subunit alpha-1S (Voltage-gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type,alpha-1 polypeptide, isoform 3, skeletal muscle). 2Show
47CACNB2CACB2_HUMANVoltage-dependent L-type calcium channel subunit beta-2 (CAB2)(Calcium channel voltage-dependent subunit beta 2) (Lambert-Eatonmyasthenic syndrome antigen B) (MYSB). 10Show
48CAPN2CAN2_HUMANCalpain-2 catalytic subunit precursor (EC (Calpain-2 largesubunit) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (M-calpain) (Millimolar-calpain) (Calpain large polypeptide L2). 2Show
49CAPSCAYP1_HUMANCalcyphosin (Calcyphosine). 1Show
50CACNG2CCG2_HUMANVoltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit). 1Show
51CCND1CCND1_HUMANG1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene). 6Show
52CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 1Show
53CEBPBCEBPB_HUMANCCAAT/enhancer-binding protein beta (C/EBP beta) (Nuclear factor NF-IL6) (Transcription factor 5). 1Show
54CETN1CETN1_HUMANCentrin-1 (Caltractin isoform 2). 2Show
55CETN2CETN2_HUMANCentrin-2 (Caltractin isoform 1). 1Show
56CFTRCFTR_HUMANCystic fibrosis transmembrane conductance regulator (CFTR) (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7). 20Show
57CGBCGHB_HUMANChoriogonadotropin subunit beta precursor (CG-beta) (Chorionicgonadotrophin chain beta). 3Show
58CLDN3CLD3_HUMANClaudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-receptor 2) (CPE-R 2) (Ventral prostate.1 protein homolog) (HRVP1). 1Show
59CYP2B6CP2B6_HUMANCytochrome P450 2B6 (EC (CYPIIB6) (P450 IIB1). 1Show
60RCSD1CPZIP_HUMANCapz-interacting protein (Protein kinase substrate CapZIP) (RCSDdomain-containing protein 1). 2Show
61CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 2Show
62CREMCREM_HUMANcAMP-responsive element modulator (Inducible cAMP early repressor)(ICER). 1Show
63CSKCSK_HUMANTyrosine-protein kinase CSK (EC (C-SRC kinase) (Protein-tyrosine kinase CYL). 1Show
64CUL5CUL5_HUMANCullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor)(VACM-1). 2Show
65GJB1CXB1_HUMANGap junction beta-1 protein (Connexin-32) (Cx32) (GAP junction 28 kDaliver protein). 2Show
66EPB49DEMA_HUMANDematin (Erythrocyte membrane protein band 4.9). 3Show
67DSPDESP_HUMANDesmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen). 3Show
68DNAJC5DNJC5_HUMANDnaJ homolog subfamily C member 5 (Cysteine string protein) (CSP). 1Show
69EEF2KEF2K_HUMANElongation factor 2 kinase (EC (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). 12Show
70ENAHENAH_HUMANProtein enabled homolog. 1Show
71EPB42EPB42_HUMANErythrocyte membrane protein band 4.2 (Erythrocyte protein 4.2)(P4.2). 2Show
72ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 2Show
73ETV1ETV1_HUMANETS translocation variant 1 (Protein ER81). 5Show
74ETV5ETV5_HUMANETS translocation variant 5 (Ets-related protein ERM). 1Show
75PFKFB1F261_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru-2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase(EC; Fructose-2,6-bisphosphatase (EC]. 1Show
76PFKFB2F262_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru-2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6-phosphofructo-2-kinase (EC; Fructose-2,6-bisphosphatase(EC]. 4Show
77PFKFB3F263_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) (Renal carcinomaantigen NY-REN-56) [Includes: 6-phosphofructo-2-kinase (EC;Fructose-2,6-bisphosphatase (EC]. 1Show
78FGF2FGF2_HUMANHeparin-binding growth factor 2 precursor (HBGF-2) (Basic fibroblastgrowth factor) (BFGF) (Prostatropin). 1Show
79FGAFIBA_HUMANFibrinogen alpha chain precursor [Contains: Fibrinopeptide A]. 1Show
80FOSFOS_HUMANProto-oncogene protein c-fos (Cellular oncogene fos) (G0/G1 switchregulatory protein 7). 2Show
81GABRB1GBRB1_HUMANGamma-aminobutyric acid receptor subunit beta-1 precursor (GABA(A)receptor subunit beta-1). 1Show
82GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 3Show
83GFPT1GFPT1_HUMANGlucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1(EC (Glutamine:fructose 6 phosphate amidotransferase 1)(Hexosephosphate aminotransferase 1) (D-fructose-6-phosphateamidotransferase 1) (GFAT 1) (GFAT1). 2Show
84GFPT2GFPT2_HUMANGlucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2(EC (Glutamine:fructose 6 phosphate amidotransferase 2)(Hexosephosphate aminotransferase 2) (D-fructose-6-phosphateamidotransferase 2) (GFAT 2) (GFAT2). 1Show
85GMFBGMFB_HUMANGlia maturation factor beta (GMF-beta). 4Show
86GNA13GNA13_HUMANGuanine nucleotide-binding protein alpha-13 subunit (G alpha-13). 3Show
87GP1BBGP1BB_HUMANPlatelet glycoprotein Ib beta chain precursor (GP-Ib beta) (GPIbB)(GPIb-beta) (Antigen CD42b-beta) (CD42c antigen). 3Show
88GPSM2GPSM2_HUMANG-protein-signaling modulator 2 (Mosaic protein LGN). 1Show
89GRIA1GRIA1_HUMANGlutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamatereceptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1). 2Show
90GRIA4GRIA4_HUMANGlutamate receptor 4 precursor (GluR-4) (GluR4) (GluR-D) (Glutamatereceptor ionotropic, AMPA 4) (AMPA-selective glutamate receptor 4). 2Show
91GRIK2GRIK2_HUMANGlutamate receptor, ionotropic kainate 2 precursor (Glutamate receptor6) (GluR-6) (GluR6) (Excitatory amino acid receptor 4) (EAA4). 3Show
92GRK7GRK7_HUMANG protein-coupled receptor kinase 7 precursor (EC (Gprotein-coupled receptor kinase GRK7). 2Show
93GSK3AGSK3A_HUMANGlycogen synthase kinase-3 alpha (EC (GSK-3 alpha). 2Show
94GSK3BGSK3B_HUMANGlycogen synthase kinase-3 beta (EC (GSK-3 beta). 2Show
95GSBSGSUB_HUMANG-substrate. 2Show
96SLC2A2GTR2_HUMANSolute carrier family 2, facilitated glucose transporter member 2(Glucose transporter type 2, liver) (GLUT-2). 6Show
97GYS1GYS1_HUMANGlycogen [starch] synthase, muscle (EC 3Show
98GYS2GYS2_HUMANGlycogen [starch] synthase, liver (EC 1Show
99HIST1H2BCH2B1C_HUMANHistone H2B type 1-C/E/F/G/I (H2B.a/g/h/k/l) (H2B.1 A) (H2B/a) (H2B/g)(H2B/h) (H2B/k) (H2B/l). 3Show
100HAND1HAND1_HUMANHeart- and neural crest derivatives-expressed protein 1(Extraembryonic tissues, heart, autonomic nervous system and neuralcrest derivatives-expressed protein 1) (eHAND). 6Show
101HDAC8HDAC8_HUMANHistone deacetylase 8 (HD8). 2Show
102HMGN1HMGN1_HUMANNon-histone chromosomal protein HMG-14 (High-mobility groupnucleosome-binding domain-containing protein 1). 5Show
103HMGN2HMGN2_HUMANNon-histone chromosomal protein HMG-17 (High-mobility groupnucleosome-binding domain-containing protein 2). 2Show
104HNF4AHNF4A_HUMANHepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factorHNF-4) (Nuclear receptor subfamily 2 group A member 1) (Transcriptionfactor 14). 1Show
105HNRPDHNRPD_HUMANHeterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich elementRNA-binding protein 1). 2Show
106HRH1HRH1_HUMANHistamine H1 receptor. 1Show
107HSF1HSF1_HUMANHeat shock factor protein 1 (HSF 1) (Heat shock transcription factor1) (HSTF 1). 1Show
108HSPB1HSPB1_HUMANHeat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27)(Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDaprotein) (28 kDa heat shock protein). 9Show
109CSF2RBIL3RB_HUMANCytokine receptor common subunit beta precursor (GM-CSF/IL-3/IL-5receptor common beta-chain) (CD131 antigen) (CDw131). 1Show
110ITPKAIP3KA_HUMANInositol-trisphosphate 3-kinase A (EC (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A). 1Show
111ITGA4ITA4_HUMANIntegrin alpha-4 precursor (Integrin alpha-IV) (VLA-4) (CD49dantigen). 2Show
112ITPR1ITPR1_HUMANInositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform1) (InsP3R1) (IP3R). 3Show
113PFKLK6PL_HUMAN6-phosphofructokinase, liver type (EC (Phosphofructokinase1) (Phosphohexokinase) (Phosphofructo-1-kinase isozyme B) (PFK-B). 1Show
114PRKAR2AKAP2_HUMANcAMP-dependent protein kinase type II-alpha regulatory subunit. 2Show
115PRKAR2BKAP3_HUMANcAMP-dependent protein kinase type II-beta regulatory subunit. 1Show
116KCNA1KCNA1_HUMANPotassium voltage-gated channel subfamily A member 1 (Voltage-gatedpotassium channel subunit Kv1.1) (HUKI) (HBK1). 2Show
117KCNA2KCNA2_HUMANPotassium voltage-gated channel subfamily A member 2 (Voltage-gatedpotassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV). 1Show
118KCNA3KCNA3_HUMANPotassium voltage-gated channel subfamily A member 3 (Voltage-gatedpotassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). 1Show
119KCNA4KCNA4_HUMANPotassium voltage-gated channel subfamily A member 4 (Voltage-gatedpotassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII). 2Show
120KCNA5KCNA5_HUMANPotassium voltage-gated channel subfamily A member 5 (Voltage-gatedpotassium channel subunit Kv1.5) (HK2) (HPCN1). 1Show
121KCNA6KCNA6_HUMANPotassium voltage-gated channel subfamily A member 6 (Voltage-gatedpotassium channel subunit Kv1.6) (HBK2). 1Show
122KCNH2KCNH2_HUMANPotassium voltage-gated channel subfamily H member 2 (Voltage-gatedpotassium channel subunit Kv11.1) (Ether-a-go-go-related genepotassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1)(Eag-related protein 1) (eag homolog). 4Show
123KCNQ2KCNQ2_HUMANPotassium voltage-gated channel subfamily KQT member 2 (Voltage-gatedpotassium channel subunit Kv7.2) (Neuroblastoma-specific potassiumchannel subunit alpha KvLQT2) (KQT-like 2). 1Show
124CAMKK1KKCC1_HUMANCalcium/calmodulin-dependent protein kinase kinase 1 (EC protein kinase kinase alpha) (CaM-kinasekinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IVkinase). 1Show
125KLF1KLF1_HUMANKrueppel-like factor 1 (Erythroid krueppel-like transcription factor)(EKLF) (Erythroid transcription factor). 1Show
126PHKA1KPB1_HUMANPhosphorylase b kinase regulatory subunit alpha, skeletal muscleisoform (Phosphorylase kinase alpha M subunit). 2Show
127PHKBKPBB_HUMANPhosphorylase b kinase regulatory subunit beta (Phosphorylase kinasesubunit beta). 2Show
128PKLRKPYR_HUMANPyruvate kinase isozymes R/L (EC (R-type/L-type pyruvatekinase) (Red cell/liver pyruvate kinase) (Pyruvate kinase 1). 1Show
129LASP1LASP1_HUMANLIM and SH3 domain protein 1 (LASP-1) (MLN 50). 1Show
130LCKLCK_HUMANProto-oncogene tyrosine-protein kinase LCK (EC (p56-LCK)(Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase). 1Show
131LIPELIPS_HUMANHormone-sensitive lipase (EC (HSL). 7Show
132ALOX5LOX5_HUMANArachidonate 5-lipoxygenase (EC (5-lipoxygenase) (5-LO). 5Show
133LRP1LRP1_HUMANProlow-density lipoprotein receptor-related protein 1 precursor (LRP)(Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor)(APOER) (CD91 antigen) [Contains: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoproteinreceptor-related protein 1 515 kDa subunit (LRP-515); Low-densitylipoprotein receptor-related protein 1 intracellular domain (LRPICD)]. 3Show
134LSP1LSP1_HUMANLymphocyte-specific protein 1 (Protein pp52) (52 kDa phosphoprotein)(Lymphocyte-specific antigen WP34) (47 kDa actin-binding protein). 5Show
135MAP3K3M3K3_HUMANMitogen-activated protein kinase kinase kinase 3 (EC kinase kinase 3) (MEK kinase 3) (MEKK 3). 5Show
136MAP2MAP2_HUMANMicrotubule-associated protein 2 (MAP 2) (MAP-2). 1Show
137MAPKAPK2MAPK2_HUMANMAP kinase-activated protein kinase 2 (EC (MAPK-activatedprotein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2). 1Show
138MBPMBP_HUMANMyelin basic protein (MBP) (Myelin A1 protein) (Myelin membraneencephalitogenic protein). 6Show
139MC4RMC4R_HUMANMelanocortin receptor 4 (MC4-R). 6Show
140ABCB1MDR1_HUMANMultidrug resistance protein 1 (EC (ATP-binding cassettesub-family B member 1) (P-glycoprotein 1) (CD243 antigen). 2Show
141NF2MERL_HUMANMerlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2)(Schwannomin) (Schwannomerlin). 1Show
142MIPMIP_HUMANLens fiber major intrinsic protein (Aquaporin-0) (MIP26) (MP26). 4Show
143MSNMOES_HUMANMoesin (Membrane-organizing extension spike protein). 1Show
144CDC25BMPIP2_HUMANM-phase inducer phosphatase 2 (EC (Dual specificityphosphatase Cdc25B). 1Show
145MYLKMYLK_HUMANMyosin light chain kinase, smooth muscle (EC (MLCK)(Telokin) (Kinase-related protein) (KRP). 1Show
146MYOM1MYOM1_HUMANMyomesin-1 (Myomesin family member 1) (190 kDa titin-associatedprotein) (190 kDa connectin-associated protein). 1Show
147MYBPC3MYPC3_HUMANMyosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein,cardiac muscle isoform). 3Show
148NCF1NCF1_HUMANNeutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDaautosomal chronic granulomatous disease protein) (Nox organizer 2)(Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A). 4Show
149NCOA1NCOA1_HUMANNuclear receptor coactivator 1 (EC (NCoA-1) (Steroidreceptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (Renalcarcinoma antigen NY-REN-52). 2Show
150PPP1R9ANEB1_HUMANNeurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-bindingprotein I) (Protein phosphatase 1 regulatory subunit 9A). 1Show
151PPP1R9BNEB2_HUMANNeurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1regulatory subunit 9B). 4Show
152NEDD4LNED4L_HUMANE3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2)(NEDD4.2). 2Show
153NFE2L1NF2L1_HUMANNuclear factor erythroid 2-related factor 1 (NF-E2-related factor 1)(NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1)(Transcription factor 11) (Transcription factor HBZ17) (Transcriptionfactor LCR-F1) (Locus control region-factor 1). 1Show
154NFATC1NFAC1_HUMANNuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcriptioncomplex cytosolic component) (NF-ATc1) (NF-ATc) (NFATc). 3Show
155NFKB1NFKB1_HUMANNuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) [Contains: Nuclear factor NF-kappa-B p50 subunit]. 3Show
156NOLC1NOLC1_HUMANNucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDanucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-bodyphosphoprotein 1). 3Show
157NOS1NOS1_HUMANNitric oxide synthase, brain (EC (NOS type I) (NeuronalNOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS). 2Show
158NOS2ANOS2A_HUMANNitric oxide synthase, inducible (EC (NOS type II)(Inducible NO synthase) (Inducible NOS) (iNOS) (Hepatocyte NOS) (HEP-NOS). 3Show
159NOS3NOS3_HUMANNitric oxide synthase, endothelial (EC (EC-NOS) (NOS typeIII) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS). 1Show
160NOXA1NOXA1_HUMANNADPH oxidase activator 1 (NOX activator 1) (P67phox-like factor)(p51-nox) (NCF2-like protein) (Antigen NY-CO-31). 2Show
161NR4A1NR4A1_HUMANNuclear receptor subfamily 4 group A member 1 (Orphan nuclear receptorHMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59). 2Show
162TBXA2RO75228_HUMANTA2R_HUMAN, BETA ISOFORM (Thromboxane A2 receptor, isoform CRA_a). 1Show
163PLA2G4APA24A_HUMANCytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA)[Includes: Phospholipase A2 (EC (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC]. 1Show
164PAWRPAWR_HUMANPRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4protein) (Par-4). 1Show
165PCTK1PCTK1_HUMANSerine/threonine-protein kinase PCTAIRE-1 (EC (PCTAIRE-motif protein kinase 1). 8Show
166PDE3BPDE3B_HUMANcGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC (CyclicGMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1). 2Show
167PDE4BPDE4B_HUMANcAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC (DPDE4)(PDE32). 2Show
168PDE4DPDE4D_HUMANcAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC (DPDE3)(PDE43). 1Show
169PDE5APDE5A_HUMANcGMP-specific 3',5'-cyclic phosphodiesterase (EC (CGB-PDE)(cGMP-binding cGMP-specific phosphodiesterase). 1Show
170PTGER4PE2R4_HUMANProstaglandin E2 receptor EP4 subtype (Prostanoid EP4 receptor) (PGEreceptor, EP4 subtype). 2Show
171SERPINF1PEDF_HUMANPigment epithelium-derived factor precursor (PEDF) (Serpin-F1) (EPC-1). 1Show
172PAHPH4H_HUMANPhenylalanine-4-hydroxylase (EC (PAH) (Phe-4-monooxygenase). 2Show
173PDCPHOS_HUMANPhosducin (PHD) (33 kDa phototransducing protein) (MEKA protein). 2Show
174PIN1PIN1_HUMANPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC Pin1) (PPIase Pin1). 1Show
175PLCB3PLCB3_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3(EC (Phosphoinositide phospholipase C) (Phospholipase C-beta-3) (PLC-beta-3). 1Show
176PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 1Show
177PLCL1PLCL1_HUMANInactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalyticallyinactive protein) (PRIP). 2Show
178FXYD1PLM_HUMANPhospholemman precursor (FXYD domain-containing ion transportregulator 1). 3Show
179LCP1PLSL_HUMANPlastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1)(LC64P). 3Show
180POU2F1PO2F1_HUMANPOU domain, class 2, transcription factor 1 (Octamer-bindingtranscription factor 1) (Oct-1) (OTF-1) (NF-A1). 1Show
181PPP1R14APP14A_HUMANProtein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiatedinhibitory protein of PP1) (CPI-17). 1Show
182PPP1R14DPP14D_HUMANProtein phosphatase 1 regulatory subunit 14D (Gastrointestinal andbrain-specific PP1-inhibitory protein 1) (GBPI-1). 1Show
183PPP1R8PP1R8_HUMANNuclear inhibitor of protein phosphatase 1 (NIPP-1) (Proteinphosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator ofRNA decay (EC 3.1.4.-) (ARD-1)]. 4Show
184PPP1R10PP1RA_HUMANSerine/threonine-protein phosphatase 1 regulatory subunit 10(Phosphatase 1 nuclear targeting subunit) (MHC class I region proline-rich protein CAT53) (FB19 protein) (PP1-binding protein of 114 kDa)(p99). 2Show
185PLNPPLA_HUMANCardiac phospholamban (PLB). 3Show
186PPP1R1APPR1A_HUMANProtein phosphatase 1 regulatory subunit 1A (Protein phosphataseinhibitor 1) (IPP-1) (I-1). 1Show
187PPP1R1BPPR1B_HUMANProtein phosphatase 1 regulatory subunit 1B (Dopamine- and cAMP-regulated neuronal phosphoprotein) (DARPP-32). 2Show
188PPP1R3APPR3A_HUMANProtein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1glycogen-associated regulatory subunit) (Protein phosphatase type-1glycogen targeting subunit). 4Show
189PSEN1PSN1_HUMANPresenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains:Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12(PS1-CTF12)]. 3Show
190PTBP1PTBP1_HUMANPolypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclearribonucleoprotein I) (hnRNP I) (57 kDa RNA-binding protein PPTB-1). 2Show
191PTPN12PTN12_HUMANTyrosine-protein phosphatase non-receptor type 12 (EC phosphatase G1) (PTPG1) (PTP-PEST). 4Show
192PTPN7PTN7_HUMANTyrosine-protein phosphatase non-receptor type 7 (EC phosphatase LC-PTP) (Hematopoietic protein-tyrosinephosphatase) (HEPTP). 2Show
193PTPRRPTPRR_HUMANReceptor-type tyrosine-protein phosphatase R precursor (EC phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase). 2Show
194CADPYR1_HUMANCAD protein [Includes: Glutamine-dependent carbamoyl-phosphatesynthase (EC; Aspartate carbamoyltransferase (EC;Dihydroorotase (EC]. 2Show
195RRADRAD_HUMANGTP-binding protein RAD (RAS associated with diabetes) (RAD1). 2Show
196RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC (Raf-1) (C-RAF) (cRaf). 8Show
197RAP1ARAP1A_HUMANRas-related protein Rap-1A precursor (GTP-binding protein smg-p21A)(Ras-related protein Krev-1) (C21KG) (G-22K). 2Show
198RAP1BRAP1B_HUMANRas-related protein Rap-1b precursor (GTP-binding protein smg p21B). 3Show
199RELREL_HUMANC-Rel proto-oncogene protein (C-Rel protein). 1Show
200RASGRF1RGRF1_HUMANRas-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guaninenucleotide-releasing protein) (Ras-specific nucleotide exchange factorCDC25) (Guanine nucleotide-releasing factor 1). 1Show
201RGS10RGS10_HUMANRegulator of G-protein signaling 10 (RGS10). 2Show
202RGS14RGS14_HUMANRegulator of G-protein signaling 14 (RGS14). 4Show
203RHOARHOA_HUMANTransforming protein RhoA precursor (H12). 2Show
204GRK1RK_HUMANRhodopsin kinase precursor (EC (RK) (G protein-coupledreceptor kinase 1). 1Show
205HNRNPA1ROA1_HUMANHeterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizingprotein) (Single-strand RNA-binding protein) (hnRNP core protein A1). 1Show
206RAP1GAPRPGP1_HUMANRap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP). 4Show
207RYR1RYR1_HUMANRyanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1)(RYR-1) (Skeletal muscle calcium release channel). 2Show
208RYR2RYR2_HUMANRyanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2)(RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel)(hRYR-2). 3Show
209SNAPAPS25BP_HUMANSNARE-associated protein Snapin (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein). 2Show
210SLC4A4S4A4_HUMANElectrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonatecotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4member 4) (kNBC1). 4Show
211SLC5A5SC5A5_HUMANSodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Sodium-iodidesymporter) (Na(+)/I(-)-symporter) (Solute carrier family 5 member 5). 1Show
212SCN7ASCN7A_HUMANSodium channel protein type 7 subunit alpha (Sodium channel proteintype VII subunit alpha) (Putative voltage-gated sodium channel subunitalpha Nax) (Sodium channel protein cardiac and skeletal muscle subunitalpha). 4Show
213SGK1SGK1_HUMANSerine/threonine-protein kinase Sgk1 (EC kinase 1). 1Show
214AANATSNAT_HUMANSerotonin N-acetyltransferase (EC (Aralkylamine N-acetyltransferase) (AA-NAT) (Serotonin acetylase). 4Show
215SNAP25SNP25_HUMANSynaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated25 kDa protein) (Super protein) (SUP). 1Show
216SOX9SOX9_HUMANTranscription factor SOX-9. 2Show
217SPTBN1SPTB2_HUMANSpectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1)(Beta-II spectrin) (Fodrin beta chain). 1Show
218SRCSRC_HUMANProto-oncogene tyrosine-protein kinase Src (EC (p60-Src) (c-Src) (pp60c-src). 2Show
219SRFSRF_HUMANSerum response factor (SRF). 2Show
220SSTR5SSR5_HUMANSomatostatin receptor type 5 (SS5R). 1Show
221STARSTAR_HUMANSteroidogenic acute regulatory protein, mitochondrial precursor (StAR)(StARD1). 2Show
222STK11STK11_HUMANSerine/threonine-protein kinase 11 (EC (Serine/threonine-protein kinase LKB1) (Renal carcinoma antigen NY-REN-19). 2Show
223STK24STK24_HUMANSerine/threonine-protein kinase 24 (EC (STE20-like kinaseMST3) (MST-3) (Mammalian STE20-like protein kinase 3). 2Show
224AURKASTK6_HUMANSerine/threonine-protein kinase 6 (EC (Aurora kinase A)(Aurora-A) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1)(Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase). 2Show
225STMN1STMN1_HUMANStathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18)(Leukemia-associated phosphoprotein p18) (pp17) (Prosolin)(Metablastin) (Protein Pr22). 5Show
226STMN2STMN2_HUMANStathmin-2 (Protein SCG10) (Superior cervical ganglion-10 protein). 2Show
227STOMSTOM_HUMANErythrocyte band 7 integral membrane protein (Stomatin) (Protein7.2b). 2Show
228STXBP5STXB5_HUMANSyntaxin-binding protein 5 (Tomosyn-1) (Lethal(2) giant larvae proteinhomolog 3). 1Show
229SISUIS_HUMANSucrase-isomaltase, intestinal [Contains: Sucrase (EC;Isomaltase (EC]. 2Show
230DARSSYDC_HUMANAspartyl-tRNA synthetase, cytoplasmic (EC (Aspartate--tRNAligase) (AspRS) (Cell proliferation-inducing gene 40 protein). 1Show
231SYN1SYN1_HUMANSynapsin-1 (Synapsin I) (Brain protein 4.1). 2Show
232SYN2SYN2_HUMANSynapsin-2 (Synapsin II). 2Show
233TAL1TAL1_HUMANT-cell acute lymphocytic leukemia protein 1 (TAL-1) (Stem cellprotein) (T-cell leukemia/lymphoma protein 5). 1Show
234MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 14Show
235RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 1Show
236THOP1THOP1_HUMANThimet oligopeptidase (EC (Endopeptidase 24.15) (MP78). 2Show
237TNNI3TNNI3_HUMANTroponin I, cardiac muscle (Cardiac troponin I). 4Show
238NGFRTNR16_HUMANTumor necrosis factor receptor superfamily member 16 precursor (Low-affinity nerve growth factor receptor) (NGF receptor) (Gp80-LNGFR)(p75 ICD) (Low affinity neurotrophin receptor p75NTR) (CD271 antigen). 2Show
239TPH1TPH1_HUMANTryptophan 5-hydroxylase 1 (EC (Tryptophan 5-monooxygenase1). 3Show
240TSC2TSC2_HUMANTuberin (Tuberous sclerosis 2 protein). 2Show
241ZFP36TTP_HUMANTristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36)(Protein TIS11A) (TIS11) (Growth factor-inducible nuclear proteinNUP475) (G0/G1 switch regulatory protein 24). 3Show
242THTY3H_HUMANTyrosine 3-monooxygenase (EC (Tyrosine 3-hydroxylase) (TH). 8Show
243UHRF1UHRF1_HUMANE3 ubiquitin-protein ligase UHRF1 (EC 6.3.2.-) (Ubiquitin-like PHD andRING finger domain-containing protein 1) (Ubiquitin-like-containingPHD and RING finger domains protein 1) (Inverted CCAAT box-bindingprotein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc fingerprotein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106). 1Show
244UNC84BUN84B_HUMANProtein unc-84 homolog B (Sad1/unc-84 protein-like 2) (Rab5-interacting protein) (Rab5IP). 3Show
245VASPVASP_HUMANVasodilator-stimulated phosphoprotein (VASP). 9Show
246VDRVDR_HUMANVitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclearreceptor subfamily 1 group I member 1). 1Show
247VIMVIME_HUMANVimentin. 13Show
248VTNVTNC_HUMANVitronectin precursor (Serum-spreading factor) (S-protein) (V75)[Contains: Vitronectin V65 subunit; Vitronectin V10 subunit;Somatomedin-B]. 3Show
249WT1WT1_HUMANWilms tumor protein (WT33). 4Show