Function: General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.
Subcellular Localization: Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1).
Rho GTPase-activating protein 7 (Rho-type GTPase-activating protein 7)(Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-relatedlipid transfer protein 12) (StARD12) (START domain-containing protein12).
Nuclease-sensitive element-binding protein 1 (Y-box-binding protein 1)(Y-box transcription factor) (YB-1) (CCAAT-binding transcriptionfactor I subunit A) (CBF-A) (Enhancer factor I subunit A) (EFI-A)(DNA-binding protein B) (DBPB).