Regulatory Network in Protein Phosphorylation
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Kinase: AKT1 v-akt murine thymoma viral oncogene homolog 1

Group: AGC      Family: Akt      

Description: v-akt murine thymoma viral oncogene homolog 1

Gene Symbol: AKT1


UniprotKB/SwissProt: AKT1_HUMAN (P31749)

Function: General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.

Subcellular Localization: Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1).

Protein Domain:

The substrate proteins of kinase AKT1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 2Show
2EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 3Show
3AKT1S1AKTS1_HUMANProline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate). 2Show
4ARANDR_HUMANAndrogen receptor (Dihydrotestosterone receptor) (Nuclear receptorsubfamily 3 group C member 4). 3Show
5ATXN1ATX1_HUMANAtaxin-1 (Spinocerebellar ataxia type 1 protein). 1Show
6BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 5Show
7BIRC4BIRC4_HUMANBaculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3ubiquitin-protein ligase XIAP) (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-likeprotein) (HILP). 1Show
8BRAFBRAF1_HUMANB-Raf proto-oncogene serine/threonine-protein kinase (EC (v-Raf murine sarcoma viral oncogene homolog B1). 2Show
9BRCA1BRCA1_HUMANBreast cancer type 1 susceptibility protein (RING finger protein 53). 1Show
10CASP9CASP9_HUMANCaspase-9 precursor (EC (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 2Show
11CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 3Show
12CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 1Show
13CHEK1CHK1_HUMANSerine/threonine-protein kinase Chk1 (EC 2Show
14CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 1Show
15EDG1EDG1_HUMANSphingosine 1-phosphate receptor Edg-1 (Sphingosine 1-phosphatereceptor 1) (S1P1). 2Show
16EP300EP300_HUMANHistone acetyltransferase p300 (EC (E1A-associated proteinp300). 1Show
17ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 1Show
18EZH2EZH2_HUMANEnhancer of zeste homolog 2 (ENX-1) (Lysine N-methyltransferase 6). 1Show
19PFKFB2F262_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru-2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6-phosphofructo-2-kinase (EC; Fructose-2,6-bisphosphatase(EC]. 2Show
20FANCAFANCA_HUMANFanconi anemia group A protein (Protein FACA). 1Show
21FOXO1FOXO1_HUMANForkhead box protein O1 (Forkhead box protein O1A) (Forkhead inrhabdomyosarcoma). 6Show
22FOXO3FOXO3_HUMANForkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21protein). 6Show
23FOXO4FOXO4_HUMANForkhead box protein O4 (Fork head domain transcription factor AFX1). 8Show
24FRAP1FRAP_HUMANFKBP12-rapamycin complex-associated protein (FK506-binding protein 12-rapamycin complex-associated protein 1) (Rapamycin target protein)(RAPT1) (Mammalian target of rapamycin) (mTOR). 2Show
25GAB2GAB2_HUMANGRB2-associated-binding protein 2 (Growth factor receptor boundprotein 2-associated protein 2) (GRB2-associated binder 2) (pp100). 2Show
26GATA1GATA1_HUMANErythroid transcription factor (GATA-binding factor 1) (GATA-1)(Eryf1) (GF-1) (NF-E1 DNA-binding protein). 1Show
27CCDC88AGRDN_HUMANGirdin (Girders of actin filament) (Coiled-coil domain-containingprotein 88A) (Akt phosphorylation enhancer) (APE) (Hook-relatedprotein 1) (HkRP1) (G alpha-interacting vesicle-associated protein)(GIV). 1Show
28GSK3AGSK3A_HUMANGlycogen synth