Regulatory Network in Protein Phosphorylation
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Kinase: AKT2 v-akt murine thymoma viral oncogene homolog 2

Group: AGC      Family: Akt      

Description: v-akt murine thymoma viral oncogene homolog 2

Gene Symbol: AKT2

Synonyms: PKBBETA, PRKBB, RAC-BETA

UniprotKB/SwissProt: AKT2_HUMAN (P31751)

Function: General protein kinase capable of phosphorylating several known proteins.

Subcellular Localization:

Protein Domain:
PDB:1GZK

The substrate proteins of kinase AKT2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1AKT1S1AKTS1_HUMANProline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate). 1Show
2BIRC4BIRC4_HUMANBaculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3ubiquitin-protein ligase XIAP) (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-likeprotein) (HILP). 2Show
3ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 2Show
4VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 1Show
5FOXO4FOXO4_HUMANForkhead box protein O4 (Fork head domain transcription factor AFX1). 1Show
6CHUKIKKA_HUMANInhibitor of nuclear factor kappa-B kinase subunit alpha(EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A)(IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinasealpha) (NFKBIKA). 1Show
7MAP3K5M3K5_HUMANMitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25)(MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1). 1Show



The substrate proteins of kinase family Akt

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 3Show
2EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 3Show
3ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 1Show
4AHNAKAHNK_HUMANNeuroblast differentiation-associated protein AHNAK (Desmoyokin). 1Show
5AKT1S1AKTS1_HUMANProline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate). 3Show
6ARANDR_HUMANAndrogen receptor (Dihydrotestosterone receptor) (Nuclear receptorsubfamily 3 group C member 4). 5Show
7C20orf74AS250_HUMAN250 kDa substrate of Akt (AS250). 3Show
8ATXN1ATX1_HUMANAtaxin-1 (Spinocerebellar ataxia type 1 protein). 2Show
9BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 9Show
10BIRC4BIRC4_HUMANBaculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3ubiquitin-protein ligase XIAP) (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-likeprotein) (HILP). 4Show
11BRAFBRAF1_HUMANB-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)(p94) (v-Raf murine sarcoma viral oncogene homolog B1). 4Show
12BRCA1BRCA1_HUMANBreast cancer type 1 susceptibility protein (RING finger protein 53). 2Show
13CASP9CASP9_HUMANCaspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 3Show
14CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 5Show
15CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 3Show
16CENTB1CENB1_HUMANCentaurin-beta-1 (Cnt-b1) (ARFGAP with coiled-coil, ANK repeat and PHdomain-containing protein 1) (ACAP1). 2Show
17CHEK1CHK1_HUMANSerine/threonine-protein kinase Chk1 (EC 2.7.11.1). 3Show
18CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 2Show
19EDG1EDG1_HUMANSphingosine 1-phosphate receptor Edg-1 (Sphingosine 1-phosphatereceptor 1) (S1P1). 3Show
20EP300EP300_HUMANHistone acetyltransferase p300 (EC 2.3.1.48) (E1A-associated proteinp300). 2Show
21ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 3Show
22EZH2EZH2_HUMANEnhancer of zeste homolog 2 (ENX-1) (Lysine N-methyltransferase 6). 1Show
23VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 1Show
24PFKFB2F262_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru-2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase(EC 3.1.3.46)]. 4