Regulatory Network in Protein Phosphorylation
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Kinase: PKCa protein kinase C, alpha

Group: AGC      Family: PKC      Subfamily: Alpha

Description: protein kinase C, alpha

Gene Symbol: PRKCA

Synonyms: AAG6, MGC129900, MGC129901, PKC-alpha, PKCA, PRKACA

UniprotKB/SwissProt: KPCA_HUMAN (P17252)

Function: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase PKCa

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1SH3BP23BP2_HUMANSH3 domain-binding protein 2 (3BP-2). 1Show
2ADRA1BADA1B_HUMANAlpha-1B adrenergic receptor (Alpha 1B-adrenoceptor) (Alpha 1B-adrenoreceptor). 5Show
3ADD1ADDA_HUMANAlpha-adducin (Erythrocyte adducin subunit alpha). 3Show
4ADD2ADDB_HUMANBeta-adducin (Erythrocyte adducin subunit beta). 2Show
5ADD3ADDG_HUMANGamma-adducin (Adducin-like protein 70). 2Show
6AHRAHR_HUMANAryl hydrocarbon receptor precursor (Ah receptor) (AhR). 2Show
7PAMAMD_HUMANPeptidyl-glycine alpha-amidating monooxygenase precursor (PAM)[Includes: Peptidylglycine alpha-hydroxylating monooxygenase(EC 1.14.17.3) (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidatinglyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]. 2