Regulatory Network in Protein Phosphorylation
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Kinase: PKCb protein kinase C, beta 1

Group: AGC      Family: PKC      Subfamily: Alpha

Description: protein kinase C, beta 1

Gene Symbol: PRKCB1

Synonyms: MGC41878, PKC-beta, PKCB, PRKCB, PRKCB2

UniprotKB/SwissProt: KPCB_HUMAN (P05771)

Function: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking (By similarity).

Subcellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).

Protein Domain:
PDB:2I0E