Regulatory Network in Protein Phosphorylation
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Kinase: PKCi protein kinase C, iota

Group: AGC      Family: PKC      Subfamily: Iota

Description: protein kinase C, iota

Gene Symbol: PRKCI

Synonyms: DXS1179E, MGC26534, PKCI, nPKC-iota

UniprotKB/SwissProt: KPCI_HUMAN (P41743)

Function: Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. May play a role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Implicated in the activation of several signaling pathways including Ras, c-Src and NF-kappa-B pathways. Functions in both pro- and anti-apoptotic pathways. Functions in the RAC1/ERK signaling required for transformed growth. Plays a role in microtubule dynamics through interaction with RAB2 and GAPDH and recruitment to vesicular tubular clusters (VTCs).

Subcellular Localization: Cytoplasm. Membrane. Endosome. Nucleus. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by cSrc, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus

Protein Domain:
PDB:1VD2

The substrate proteins of kinase PKCi

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 1Show
2RPS6KB2KS6B2_HUMANRibosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDaribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinasebeta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14beta). 1Show



The substrate proteins of kinase family PKC

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1YWHAB1433B_HUMAN14-3-3 protein beta/alpha (Protein kinase C inhibitor protein 1)(KCIP-1) (Protein 1054). 5Show
2YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 1Show
3HLA-A1A01_HUMANHLA class I histocompatibility antigen, A-1 alpha chain precursor (MHCclass I antigen A*1). 1Show
4SH3BP23BP2_HUMANSH3 domain-binding protein 2 (3BP-2). 1Show
5EPB4141_HUMANProtein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R). 2Show
6ADRA1BADA1B_HUMANAlpha-1B adrenergic receptor (Alpha 1B-adrenoceptor) (Alpha 1B-adrenoreceptor). 5Show
7ADRA2AADA2A_HUMANAlpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtypeC10). 2Show
8ADD1ADDA_HUMANAlpha-adducin (Erythrocyte adducin subunit alpha). 7Show
9ADD2ADDB_HUMANBeta-adducin (Erythrocyte adducin subunit beta). 7Show
10ADD3ADDG_HUMANGamma-adducin (Adducin-like protein 70). 4Show
11ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 4Show
12AHRAHR_HUMANAryl hydrocarbon receptor precursor (Ah receptor) (AhR). 2Show
13AKT3AKT3_HUMANRAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma)(Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2). 2Show
14PAMAMD_HUMANPeptidyl-glycine alpha-amidating monooxygenase precursor (PAM)[Includes: Peptidylglycine alpha-hydroxylating monooxygenase(EC 1.14.17.3) (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidatinglyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]. 4Show
15ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 5Show
16ANXA2ANXA2_HUMANAnnexin A2 (Annexin-2) (Annexin II) (Lipocortin II) (Calpactin I heavychain) (Chromobindin-8) (p36) (Protein I) (Placental anticoagulantprotein IV) (PAP-IV). 4Show
17APLP2APLP2_HUMANAmyloid-like protein 2 precursor (Amyloid protein homolog) (APPH)(CDEI box-binding protein) (CDEBP). 2Show
18ADRBK1ARBK1_HUMANBeta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2). 4Show
19ASGR2ASGR2_HUMANAsialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (Hepatic lectinH2). 1Show
20ATP1A1AT1A1_HUMANSodium/potassium-transporting ATPase subunit alpha-1 precursor(EC 3.6.3.9) (Sodium pump subunit alpha-1) (Na(+)/K(+) ATPase alpha-1subunit). 1Show
21ATP2B1AT2B1_HUMANPlasma membrane calcium-transporting ATPase 1 (EC 3.6.3.8) (PMCA1)(Plasma membrane calcium pump isoform 1) (Plasma membrane calciumATPase isoform 1).