|Group: AGC Family: PKC Subfamily: Alpha|
Description: protein kinase C, beta 1
Gene Symbol: PRKCB1
Synonyms: MGC41878, PKC-beta, PKCB, PRKCB, PRKCB2
UniprotKB/SwissProt: KPCB_HUMAN (P05771)
Function: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking (By similarity).
Subcellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).