Regulatory Network in Protein Phosphorylation
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Kinase: PKCt protein kinase C, theta

Group: AGC      Family: PKC      Subfamily: Delta

Description: protein kinase C, theta

Gene Symbol: PRKCQ

Synonyms: MGC126514, MGC141919, PRKCT, nPKC-theta

UniprotKB/SwissProt: KPCT_HUMAN (Q04759)

Function: This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Subcellular Localization:

Protein Domain:
PDB:1XJD

The substrate proteins of kinase PKCt

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1RASGRP3GRP3_HUMANRas guanyl-releasing protein 3 (Calcium and DAG-regulated guaninenucleotide exchange factor III) (Guanine nucleotide exchange factorfor Rap1). 1Show
2HABP4HABP4_HUMANIntracellular hyaluronan-binding protein 4 (IHABP4) (Ki-1/57intracellular antigen). 2Show
3ICAM3ICAM3_HUMANIntercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CD50antigen) (CDw50). 2Show
4CHUKIKKA_HUMANInhibitor of nuclear factor kappa-B kinase subunit alpha(EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A)(IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinasealpha) (NFKBIKA). 2Show
5IKBKBIKKB_HUMANInhibitor of nuclear factor kappa-B kinase subunit beta (EC 2.7.11.10)(I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB). 2Show
6IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 2Show
7PRKCQKPCT_HUMANProtein kinase C theta type (EC 2.7.11.13) (nPKC-theta). 2Show
8MSNMOES_HUMANMoesin (Membrane-organizing extension spike protein). 2Show
9STK39STK39_HUMANSTE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1)(Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT). 4Show
10WIPF1WIPF1_HUMANWAS/WASL-interacting protein family member 1 (Wiskott-Aldrich syndromeprotein-interacting protein) (WASP-interacting protein) (PRPL-2protein). 2Show



The substrate proteins of kinase family PKC

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1YWHAB1433B_HUMAN14-3-3 protein beta/alpha (Protein kinase C inhibitor protein 1)(KCIP-1) (Protein 1054). 5Show
2YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 1Show
3HLA-A1A01_HUMANHLA class I histocompatibility antigen, A-1 alpha chain precursor (MHCclass I antigen A*1). 1Show
4SH3BP23BP2_HUMANSH3 domain-binding protein 2 (3BP-2). 1Show
5EPB4141_HUMANProtein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R). 2Show
6ADRA1BADA1B_HUMANAlpha-1B adrenergic receptor (Alpha 1B-adrenoceptor) (Alpha 1B-adrenoreceptor). 5Show
7ADRA2AADA2A_HUMANAlpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtypeC10). 2Show
8ADD1ADDA_HUMANAlpha-adducin (Erythrocyte adducin subunit alpha). 7Show
9ADD2ADDB_HUMANBeta-adducin (Erythrocyte adducin subunit beta). 7Show
10ADD3ADDG_HUMANGamma-adducin (Adducin-like protein 70). 4Show
11ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 4Show
12AHRAHR_HUMANAryl hydrocarbon receptor precursor (Ah receptor) (AhR). 2Show
13AKT3AKT3_HUMANRAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma)(Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2). 2Show
14PAMAMD_HUMANPeptidyl-glycine alpha-amidating monooxygenase precursor (PAM)[Includes: Peptidylglycine alpha-hydroxylating monooxygenase(EC 1.14.17.3) (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidatinglyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]. 4Show
15ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 5Show
16ANXA2ANXA2_HUMANAnnexin A2 (Annexin-2) (Annexin II) (Lipocortin II) (Calpactin I heavychain) (Chromobindin-8) (p36) (Protein I) (Placental anticoagulantprotein IV) (PAP-IV). 4Show
17APLP2APLP2_HUMANAmyloid-like protein 2 precursor (Amyloid protein homolog) (APPH)(CDEI box-binding protein) (CDEBP). 2Show
18ADRBK1ARBK1_HUMANBeta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2). 4Show
19ASGR2ASGR2_HUMANAsialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (Hepatic lectinH2). 1Show
20ATP1A1AT1A1_HUMANSodium/potassium-transporting ATPase subunit alpha-1 precursor(EC 3.6.3.9) (Sodium pump subunit alpha-1) (Na(+)/K(+) ATPase alpha-1subunit). 1Show
21ATP2B1AT2B1_HUMANPlasma membrane calcium-transporting ATPase 1 (EC 3.6.3.8) (PMCA1)(Plasma membrane calcium pump isoform 1) (Plasma membrane calciumATPase isoform 1). 2Show
22ATP2B2AT2B2_HUMANPlasma membrane calcium-transporting ATPase 2 (EC 3.6.3.8) (PMCA2)(Plasma membrane calcium pump isoform 2) (Plasma membrane calciumATPase isoform 2). 2Show
23ATP2B3AT2B3_HUMANPlasma membrane calcium-transporting ATPase 3 (EC 3.6.3.8) (PMCA3)(Plasma membrane calcium pump isoform 3) (Plasma membrane calciumATPase isoform 3). 1Show
24ATP2B4AT2B4_HUMANPlasma membrane calcium-transporting ATPase 4 (EC 3.6.3.8) (PMCA4)(Plasma membrane calcium pump isoform 4) (Plasma membrane calciumATPase isoform 4) (Matrix-remodeling-associated protein 1). 1Show
25ATF2ATF2_HUMANCyclic AMP-dependent transcription factor ATF-2 (Activatingtranscription factor 2) (cAMP response element-binding protein CRE-BP1) (HB16). 2Show
26SLC4A3B3A3_HUMANAnion exchange protein 3 (Neuronal band 3-like protein) (Solutecarrier family 4 member 3) (Cardiac/brain band 3-like protein)(CAE3/BAE3). 2Show
27BCL2BCL2_HUMANApoptosis regulator Bcl-2. 2Show
28BDKRB2BKRB2_HUMANB2 bradykinin receptor (BK-2 receptor) (B2R). 2Show
29BNC1BNC1_HUMANZinc finger protein basonuclin-1. 1Show