Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: PKCe protein kinase C, epsilon

Group: AGC      Family: PKC      Subfamily: Eta

Description: protein kinase C, epsilon

Gene Symbol: PRKCE

Synonyms: MGC125656, MGC125657, PKCE, nPKC-epsilon

UniprotKB/SwissProt: KPCE_HUMAN (Q02156)

Function: This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase PKCe

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1SLC4A3B3A3_HUMANAnion exchange protein 3 (Neuronal band 3-like protein) (Solutecarrier family 4 member 3) (Cardiac/brain band 3-like protein)(CAE3/BAE3). 2Show
2CENTA1CENA1_HUMANCentaurin-alpha-1 (Putative MAPK-activating protein PM25). 2Show
3GJA1CXA1_HUMANGap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDaheart protein). 1Show
4IQGAP1IQGA1_HUMANRas GTPase-activating-like protein IQGAP1 (p195). 1Show
5KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 3Show
6PRKCEKPCE_HUMANProtein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon). 3Show
7RPS6KB2KS6B2_HUMANRibosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDaribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinasebeta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14beta). 1Show
8METMET_HUMANHepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGFreceptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor)(Met proto-oncogene tyrosine kinase) (c-Met). 1Show
9OPRD1OPRD_HUMANDelta-type opioid receptor (DOR-1). 1Show
10PPP1R14APP14A_HUMANProtein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiatedinhibitory protein of PP1) (CPI-17). 2Show
11TICAM2TCAM2_HUMANTIR domain-containing adapter molecule 2 (TICAM-2) (TRIF-relatedadapter molecule) (Toll/interleukin-1 receptor domain-containingprotein) (Toll-like receptor adaptor protein 3) (Putative NF-kappa-B-activating protein 502). 1Show
12TNNI3TNNI3_HUMANTroponin I, cardiac muscle (Cardiac troponin I). 1Show
13TRPV1TRPV1_HUMANTransient receptor potential cation channel subfamily V member 1(TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)(Capsaicin receptor). 6Show



The substrate proteins of kinase family PKC

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1YWHAB1433B_HUMAN14-3-3 protein beta/alpha (Protein kinase C inhibitor protein 1)(KCIP-1) (Protein 1054). 5Show
2YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 1Show
3HLA-A1A01_HUMANHLA class I histocompatibility antigen, A-1 alpha chain precursor (MHCclass I antigen A*1). 1Show
4SH3BP23BP2_HUMANSH3 domain-binding protein 2 (3BP-2). 1Show
5EPB4141_HUMANProtein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R). 2Show
6ADRA1BADA1B_HUMANAlpha-1B adrenergic receptor (Alpha 1B-adrenoceptor) (Alpha 1B-adrenoreceptor). 5Show
7ADRA2AADA2A_HUMANAlpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtypeC10). 2Show
8ADD1ADDA_HUMANAlpha-adducin (Erythrocyte adducin subunit alpha). 7Show
9ADD2ADDB_HUMANBeta-adducin (Erythrocyte adducin subunit beta). 7Show
10ADD3ADDG_HUMANGamma-adducin (Adducin-like protein 70). 4Show
11ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 4Show
12AHRAHR_HUMANAryl hydrocarbon receptor precursor (Ah receptor) (AhR). 2Show
13AKT3AKT3_HUMANRAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma)(Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2). 2Show
14PAMAMD_HUMANPeptidyl-glycine alpha-amidating monooxygenase precursor (PAM)[Includes: Peptidylglycine alpha-hydroxylating monooxygenase(EC 1.14.17.3) (PHM); Pept