Regulatory Network in Protein Phosphorylation
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Kinase: PKG2 protein kinase, cGMP-dependent, type II

Group: AGC      Family: PKG      

Description: protein kinase, cGMP-dependent, type II

Gene Symbol: PRKG2

Synonyms: PRKGR2, cGKII

UniprotKB/SwissProt: KGP2_HUMAN (Q13237)


Subcellular Localization:

Protein Domain:

The substrate proteins of kinase PKG2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1LASP1LASP1_HUMANLIM and SH3 domain protein 1 (LASP-1) (MLN 50). 3Show
2PLCB3PLCB3_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3(EC (Phosphoinositide phospholipase C) (Phospholipase C-beta-3) (PLC-beta-3). 4Show
3PTSPTPS_HUMAN6-pyruvoyl tetrahydrobiopterin synthase (EC (PTPS) (PTPsynthase). 1Show

The substrate proteins of kinase family PKG

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CFTRCFTR_HUMANCystic fibrosis transmembrane conductance regulator (CFTR) (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7). 12Show
2CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 1Show
3CRIP2CRIP2_HUMANCysteine-rich protein 2 (CRP2) (Protein ESP1). 2Show
4FHOD1FHOD1_HUMANFH1/FH2 domain-containing protein 1 (Formin homolog overexpressed inspleen 1) (FHOS) (Formin homology 2 domain-containing protein 1). 1Show
5GKAP1GKAP1_HUMANG kinase-anchoring protein 1 (cGMP-dependent protein kinase-anchoringprotein of 42 kDa). 1Show
6GPSM2GPSM2_HUMANG-protein-signaling modulator 2 (Mosaic protein LGN). 3Show
7GRIA2GRIA2_HUMANGlutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamatereceptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2). 1Show
8GSBSGSUB_HUMANG-substrate. 4Show
9GTF2IGTF2I_HUMANGeneral transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosinekinase-associated protein 135) (BTK-associated protein 135) (BAP-135)(SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndromechromosomal region 6 protein). 4Show
10HMGN2HMGN2_HUMANNon-histone chromosomal protein HMG-17 (High-mobility groupnucleosome-binding domain-containing protein 2). 1Show
11HRH1HRH1_HUMANHistamine H1 receptor. 2Show
12ITPR1ITPR1_HUMANInositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform1) (InsP3R1) (IP3R). 1Show
13LASP1LASP1_HUMANLIM and SH3 domain protein 1 (LASP-1) (MLN 50). 3Show
14MRVI1MRVI1_HUMANProtein MRVI1 (Inositol 1,4,5-triphosphate receptor-associated cGMPkinase substrate) (JAW1-related protein MRVI1). 1Show
15SPP1OSTP_HUMANOsteopontin precursor (Bone sialoprotein 1) (Secreted phosphoprotein1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin). 1Show
16PDE5APDE5A_HUMANcGMP-specific 3',5'-cyclic phosphodiesterase (EC (CGB-PDE)(cGMP-binding cGMP-specific phosphodiesterase). 2Show
17PLCB3PLCB3_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3(EC (Phosphoinositide phospholipase C) (Phospholipase C-beta-3) (PLC-beta-3). 6Show
18PTSPTPS_HUMAN6-pyruvoyl tetrahydrobiopterin synthase (EC (PTPS) (PTPsynthase). 2Show
19RAP1BRAP1B_HUMANRas-related protein Rap-1b precursor (GTP-binding protein smg p21B). 1Show
20RGS2RGS2_HUMANRegulator of G-protein signaling 2 (RGS2) (G0/G1 switch regulatoryprotein 8). 4Show
21GARNL4RPGP2_HUMANRap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activatingRap/Ran-GAP domain-like protein 4). 1Show
22RYR1RYR1_HUMANRyanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1)(RYR-1) (Skeletal muscle calcium release channel). 2Show
23SEPT3SEPT3_HUMANNeuronal-specific septin-3. 2Show
24SF1SF01_HUMANSplicing factor 1 (Zinc finger protein 162) (Transcription factorZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-bindingprotein mBBP) (BBP). 3Show
25TRPC3TRPC3_HUMANShort transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3). 2Show
26VASPVASP_HUMANVasodilator-stimulated phosphoprotein (VASP). 9Show