Regulatory Network in Protein Phosphorylation
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Kinase: MSK1 ribosomal protein S6 kinase, 90kDa, polypeptide 5

Group: AGC      Family: RSK      Subfamily: MSK

Description: ribosomal protein S6 kinase, 90kDa, polypeptide 5

Gene Symbol: RPS6KA5

Synonyms: MGC1911, MSK1, MSPK1, RLPK

UniprotKB/SwissProt: KS6A5_HUMAN (O75582)

Function: Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

Subcellular Localization: Nucleus. Cytoplasm. Note=Predominantly nuclear. Partially cytoplasmic.

Protein Domain:
PDB:1VZO

The substrate proteins of kinase MSK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 3Show
2ATF1ATF1_HUMANCyclic AMP-dependent transcription factor ATF-1 (Activatingtranscription factor 1) (TREB36 protein). 2Show
3BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 1Show
4CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 1Show
5ETV1ETV1_HUMANETS translocation variant 1 (Protein ER81). 3Show
6HIST1H2AGH2A1_HUMANHistone H2A type 1 (H2A.1) (H2A/p). 1Show
7HIST3H2AH2A3_HUMANHistone H2A type 3. 1Show
8HIST3H3H31T_HUMANHistone H3.1t (H3t) (H3/t) (H3/g). 2Show
9HMGN1HMGN1_HUMANNon-histone chromosomal protein HMG-14 (High-mobility groupnucleosome-binding domain-containing protein 1). 4Show
10RPS6KA5KS6A5_HUMANRibosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6kinase 5) (RSK-like protein kinase) (RSKL). 6Show
11NR4A1NR4A1_HUMANNuclear receptor subfamily 4 group A member 1 (Orphan nuclear receptorHMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59). 1Show
12PLA2G4APA24A_HUMANCytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA)[Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]. 1Show
13STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 1Show
14STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 2Show
15STK11STK11_HUMANSerine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine-protein kinase LKB1) (Renal carcinoma antigen NY-REN-19). 1Show
16RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 2Show
17THTY3H_HUMANTyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH). 1Show



The substrate proteins of kinase family MSK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 3Show
2ATF1ATF1_HUMANCyclic AMP-dependent transcription factor ATF-1 (Activatingtranscription factor 1) (TREB36 protein). 3Show
3BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 1Show
4CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 2Show
5ETV1ETV1_HUMANETS translocation variant 1 (Protein ER81). 3Show
6HIST1H2AGH2A1_HUMANHistone H2A type 1 (H2A.1) (H2A/p). 1Show
7HIST3H2AH2A3_HUMANHistone H2A type 3. 1Show
8HIST3H3H31T_HUMANHistone H3.1t (H3t) (H3/t) (H3/g). 2Show
9HMGN1HMGN1_HUMANNon-histone chromosomal protein HMG-14 (High-mobility groupnucleosome-binding domain-containing protein 1). 5Show
10RPS6KA5KS6A5_HUMANRibosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6kinase 5) (RSK-like protein kinase) (RSKL). 6Show
11NR4A1NR4A1_HUMANNuclear receptor subfamily 4 group A member 1 (Orphan nuclear receptorHMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59). 1Show
12PLA2G4APA24A_HUMANCytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA)[Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]. 1Show
13STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 1Show
14STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 2Show
15STK11STK11_HUMANSerine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine-protein kinase LKB1) (Renal carcinoma antigen NY-REN-19). 1Show
16RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 2Show
17THTY3H_HUMANTyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH). 1Show