Regulatory Network in Protein Phosphorylation
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Kinase: RSK1 ribosomal protein S6 kinase, 90kDa, polypeptide 2

Group: AGC      Family: RSK      Subfamily: RSK

Description: ribosomal protein S6 kinase, 90kDa, polypeptide 2

Gene Symbol: RPS6KA2

Synonyms: HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3

UniprotKB/SwissProt: KS6A2_HUMAN (Q15349)

Function: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

Subcellular Localization: Nucleus.

Protein Domain:

The substrate proteins of kinase RSK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 4Show
2CEBPBCEBPB_HUMANCCAAT/enhancer-binding protein beta (C/EBP beta) (Nuclear factor NF-IL6) (Transcription factor 5). 1Show
3CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 1Show
4ESR2ESR2_HUMANEstrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group Amember 2). 1Show
5ETV1ETV1_HUMANETS translocation variant 1 (Protein ER81). 3Show
6NFKBIBIKBB_HUMANNF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta)(IkappaBbeta) (IkB-beta) (IkB-B) (Thyroid receptor-interacting protein9) (TRIP-9) (TR-interacting protein 9). 2Show
7L1CAML1CAM_HUMANNeural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen). 1Show