Regulatory Network in Protein Phosphorylation
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Kinase: RSK4 ribosomal protein S6 kinase, 90kDa, polypeptide 6

Group: AGC      Family: RSK      Subfamily: RSK

Description: ribosomal protein S6 kinase, 90kDa, polypeptide 6

Gene Symbol: RPS6KA6

Synonyms: RSK4

UniprotKB/SwissProt: KS6A6_HUMAN (Q9UK32)

Function: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase family RSK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ATF1ATF1_HUMANCyclic AMP-dependent transcription factor ATF-1 (Activatingtranscription factor 1) (TREB36 protein). 1Show
2ATF4ATF4_HUMANCyclic AMP-dependent transcription factor ATF-4 (Activatingtranscription factor 4) (DNA-binding protein TAXREB67) (Cyclic AMPresponse element-binding protein 2) (CREB2). 1Show
3BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 7Show
4CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 1Show
5CEBPBCEBPB_HUMANCCAAT/enhancer-binding protein beta (C/EBP beta) (Nuclear factor NF-IL6) (Transcription factor 5). 2Show
6CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 4Show
7DAPK1DAPK1_HUMANDeath-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1). 1Show
8EEF2KEF2K_HUMANElongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). 2Show
9ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 4Show
10ESR2ESR2_HUMANEstrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group Amember 2). 1Show
11ETV1ETV1_HUMANETS translocation variant 1 (Protein ER81). 6Show
12FLNAFLNA_HUMANFilamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-bindingprotein) (Actin-binding protein 280) (ABP-280) (Non-muscle filamin). 1Show
13FOSFOS_HUMANProto-oncogene protein c-fos (Cellular oncogene fos) (G0/G1 switchregulatory protein 7). 2Show
14GMFBGMFB_HUMANGlia maturation factor beta (GMF-beta). 2Show
15GSK3BGSK3B_HUMANGlycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta). 1Show
16HIST1H2AGH2A1_HUMANHistone H2A type 1 (H2A.1) (H2A/p). 1Show
17HIST3H3H31T_HUMANHistone H3.1t (H3t) (H3/t) (H3/g). 1Show
18HMGN1HMGN1_HUMANNon-histone chromosomal protein HMG-14 (High-mobility groupnucleosome-binding domain-containing protein 1). 3Show
19HMGN2HMGN2_HUMANNon-histone chromosomal protein HMG-17 (High-mobility groupnucleosome-binding domain-containing protein 2). 2Show
20NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 1Show
21NFKBIBIKBB_HUMANNF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta)(IkappaBbeta) (IkB-beta) (IkB-B) (Thyroid receptor-interacting protein9) (TRIP-9) (TR-interacting protein 9). 2Show
22KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 1Show
23RPS6KA1KS6A1_HUMANRibosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1)(RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a)(MAPKAPK1A). 2Show
24RPS6KA5KS6A5_HUMANRibosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6kinase 5) (RSK-like protein kinase) (RSKL). 6Show
25L1CAML1CAM_HUMANNeural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen). 2Show
26CDC25BMPIP2_HUMANM-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25B). 1Show
27CDC25CMPIP3_HUMANM-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25C). 4Show
28NFATC4NFAC4_HUMANNuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4)(T-cell transcription factor NFAT3) (NF-AT3). 1Show
29NR4A1NR4A1_HUMANNuclear receptor subfamily 4 group A member 1 (Orphan nuclear receptorHMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59). 2Show
30NR4A2NR4A2_HUMANNuclear receptor subfamily 4 group A member 2 (Orphan nuclear receptorNURR1) (Immediate-early response protein NOT) (Transcriptionally-inducible nuclear receptor). 1Show
31TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 1Show
32PPP1R3APPR3A_HUMANProtein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1glycogen-associated regulatory subunit) (Protein phosphatase type-1glycogen targeting subunit). 3Show
33RRN3RRN3_HUMANRNA polymerase I-specific transcription initiation factor RRN3(Transcription initiation factor IA) (TIF-IA). 1Show
34SLC9A1SL9A1_HUMANSodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solutecarrier family 9 member 1) (Na(+)/H(+) antiporter, amiloride-sensitive) (APNH). 1Show
35SRFSRF_HUMANSerum response factor (SRF). 2Show
36STK11STK11_HUMANSerine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine-protein kinase LKB1) (Renal carcinoma antigen NY-REN-19). 2Show
37MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 1Show
38RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 1Show
39TSC2TSC2_HUMANTuberin (Tuberous sclerosis 2 protein). 1Show
40WEE1WEE1_HUMANWee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). 3Show