Regulatory Network in Protein Phosphorylation
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Kinase: p70S6K ribosomal protein S6 kinase, 70kDa, polypeptide 1

Group: AGC      Family: RSK      Subfamily: p70

Description: ribosomal protein S6 kinase, 70kDa, polypeptide 1

Gene Symbol: RPS6KB1

Synonyms: PS6K, S6K, S6K1, STK14A, p70(S6K)-alpha, p70-S6K, p70-alpha

UniprotKB/SwissProt: KS6B1_HUMAN (P23443)

Function: Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.

Subcellular Localization: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity).

Protein Domain:

The substrate proteins of kinase p70S6K

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1EEF2KEF2K_HUMANElongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). 2Show
2FRAP1FRAP_HUMANFKBP12-rapamycin complex-associated protein (FK506-binding protein 12-rapamycin complex-associated protein 1) (Rapamycin target protein)(RAPT1) (Mammalian target of rapamycin) (mTOR). 2Show
3HSPB1HSPB1_HUMANHeat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27)(Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDaprotein) (28 kDa heat shock protein). 2Show
4EIF4BIF4B_HUMANEukaryotic translation initiation factor 4B (eIF-4B). 1Show
5KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 1Show
6RPS6KB1KS6B1_HUMANRibosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha). 1Show
7POLDIP3PDIP3_HUMANPolymerase delta-interacting protein 3 (46 kDa DNA polymerase deltainteraction protein) (p46). 1Show
8STK11STK11_HUMANSerine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine-protein kinase LKB1) (Renal carcinoma antigen NY-REN-19). 1Show



The substrate proteins of kinase family p70

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1DBNLDBNL_HUMANDrebrin-like protein (SH3 domain-containing protein 7) (Drebrin-F)(Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55)(Cervical mucin-associated protein). 4Show
2DUSP3DUS3_HUMANDual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16)(Dual specificity protein phosphatase VHR). 2Show
3EEF2KEF2K_HUMANElongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). 2Show
4FRAP1FRAP_HUMANFKBP12-rapamycin complex-associated protein (FK506-binding protein 12-rapamycin complex-associated protein 1) (Rapamycin target protein)(RAPT1) (Mammalian target of rapamycin) (mTOR). 2Show
5GAB2GAB2_HUMANGRB2-associated-binding protein 2 (Growth factor receptor boundprotein 2-associated protein 2) (GRB2-associated binder 2) (pp100). 2Show
6HSPB1HSPB1_HUMANHeat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27)(Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDaprotein) (28 kDa heat shock protein). 2Show
7EIF4BIF4B_HUMANEukaryotic translation initiation factor 4B (eIF-4B). 1Show
8KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 1Show
9RPS6KB1KS6B1_HUMANRibosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha). 1Show
10LATLAT_HUMANLinker for activation of T-cells family member 1 (36 kDa phospho-tyrosine adapter protein) (pp36) (p36-38). 5Show
11LCP2LCP2_HUMANLymphocyte cytosolic protein 2 (SH2 domain-containing leukocyteprotein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76). 6Show
12MAPK14MK14_HUMANMitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activatedprotein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressiveanti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP)(MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A). 1Show
13MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 1Show
14POLDIP3PDIP3_HUMANPolymerase delta-interacting protein 3 (46 kDa DNA polymerase deltainteraction protein) (p46). 1Show
15RPS6RS6_HUMAN40S ribosomal protein S6 (Phosphoprotein NP33). 2Show
16SH2B3SH2B3_HUMANSH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)(Signal transduction protein Lnk) (Lymphocyte adapter protein). 2Show
17SHC1SHC1_HUMANSHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2domain-containing-transforming protein C1). 5Show
18STK11STK11_HUMANSerine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine-protein kinase LKB1) (Renal carcinoma antigen NY-REN-19). 1Show
19ZAP70ZAP70_HUMANTyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associatedprotein) (Syk-related tyrosine kinase). 10Show