Regulatory Network in Protein Phosphorylation
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Kinase: SGK1 serum/glucocorticoid regulated kinase

Group: AGC      Family: SGK      

Description: serum/glucocorticoid regulated kinase

Gene Symbol: SGK

Synonyms: SGK1

UniprotKB/SwissProt: SGK1_HUMAN (O00141)

Function: Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1.

Subcellular Localization: Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Nuclear, upon phosphorylation.

Protein Domain:

The substrate proteins of kinase SGK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1BRAFBRAF1_HUMANB-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)(p94) (v-Raf murine sarcoma viral oncogene homolog B1). 1Show
2CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 1Show
3SLC1A3EAA1_HUMANExcitatory amino acid transporter 1 (Solute carrier family 1 member 3)(Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1). 1Show
4FOXO3FOXO3_HUMANForkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21protein). 4Show
5GSK3AGSK3A_HUMANGlycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha). 1Show
6NEDD4LNED4L_HUMANE3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2)(NEDD4.2). 4Show



The substrate proteins of kinase family SGK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1BRAFBRAF1_HUMANB-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)(p94) (v-Raf murine sarcoma viral oncogene homolog B1). 2Show
2CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 2Show
3SLC1A3EAA1_HUMANExcitatory amino acid transporter 1 (Solute carrier family 1 member 3)(Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1). 1Show
4FOXO1FOXO1_HUMANForkhead box protein O1 (Forkhead box protein O1A) (Forkhead inrhabdomyosarcoma). 3Show
5FOXO3FOXO3_HUMANForkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21protein). 7Show
6GSK3AGSK3A_HUMANGlycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha). 2Show
7GSK3BGSK3B_HUMANGlycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta). 3Show
8HDHD_HUMANHuntingtin (Huntington disease protein) (HD protein). 1Show
9KCNJ1IRK1_HUMANATP-sensitive inward rectifier potassium channel 1 (Potassium channel,inwardly rectifying subfamily J member 1) (ATP-regulated potassiumchannel ROM-K) (Kir1.1). 1Show
10MAP3K3M3K3_HUMANMitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25)(MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3). 2Show
11NDRG2NDRG2_HUMANProtein NDRG2 (Protein Syld709613). 3Show
12NEDD4LNED4L_HUMANE3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2)(NEDD4.2). 7Show