Regulatory Network in Protein Phosphorylation
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Kinase: SGK3 serum/glucocorticoid regulated kinase family, member 3

Group: AGC      Family: SGK      

Description: serum/glucocorticoid regulated kinase family, member 3

Gene Symbol: SGK3

Synonyms: CISK, DKFZp781N0293, SGK2, SGKL

UniprotKB/SwissProt: SGK3_HUMAN (Q96BR1)

Function: Involved in the activation of potassium channels. Mediates cell IL-3-dependent survival signals (By similarity).

Subcellular Localization: Cytoplasmic vesicle (By similarity). Early endosome (By similarity). Note=Localized in vesicle-like structures and in the early endosome (By similarity).

Protein Domain:

The substrate proteins of kinase SGK3

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1GSK3AGSK3A_HUMANGlycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha). 1Show
2GSK3BGSK3B_HUMANGlycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta). 2Show



The substrate proteins of kinase family SGK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1BRAFBRAF1_HUMANB-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)(p94) (v-Raf murine sarcoma viral oncogene homolog B1). 2Show
2CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 2Show
3SLC1A3EAA1_HUMANExcitatory amino acid transporter 1 (Solute carrier family 1 member 3)(Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1). 1Show
4FOXO1FOXO1_HUMANForkhead box protein O1 (Forkhead box protein O1A) (Forkhead inrhabdomyosarcoma). 3Show
5FOXO3FOXO3_HUMANForkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21protein). 7Show
6GSK3AGSK3A_HUMANGlycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha). 2Show
7GSK3BGSK3B_HUMANGlycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta). 3Show
8HDHD_HUMANHuntingtin (Huntington disease protein) (HD protein). 1Show
9KCNJ1IRK1_HUMANATP-sensitive inward rectifier potassium channel 1 (Potassium channel,inwardly rectifying subfamily J member 1) (ATP-regulated potassiumchannel ROM-K) (Kir1.1). 1Show
10MAP3K3M3K3_HUMANMitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25)(MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3). 2Show
11NDRG2NDRG2_HUMANProtein NDRG2 (Protein Syld709613). 3Show
12NEDD4LNED4L_HUMANE3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2)(NEDD4.2). 7Show