|Group: Atypical Family: Alpha Subfamily: ChaK|
Description: transient receptor potential cation channel, subfamily M, member 7
Gene Symbol: TRPM7
Synonyms: CHAK, CHAK1, FLJ20117, FLJ25718, LTRPC7, TRP-PLIK
UniprotKB/SwissProt: TRPM7_HUMAN (Q96QT4)
Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Subcellular Localization: Membrane; Multi-pass membrane protein (Probable).