Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: ChaK1 transient receptor potential cation channel, subfamily M, member 7

Group: Atypical      Family: Alpha      Subfamily: ChaK

Description: transient receptor potential cation channel, subfamily M, member 7

Gene Symbol: TRPM7

Synonyms: CHAK, CHAK1, FLJ20117, FLJ25718, LTRPC7, TRP-PLIK

UniprotKB/SwissProt: TRPM7_HUMAN (Q96QT4)

Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

Subcellular Localization: Membrane; Multi-pass membrane protein (Probable).

Protein Domain:

The substrate proteins of kinase ChaK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 2Show



The substrate proteins of kinase family ChaK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 2Show