|Group: Atypical Family: Alpha Subfamily: ChaK|
Description: transient receptor potential cation channel, subfamily M, member 6
Gene Symbol: TRPM6
Synonyms: CHAK2, HMGX, HOMG, HSH
UniprotKB/SwissProt: TRPM6_HUMAN (Q9BX84)
Function: Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
Subcellular Localization: Membrane; Multi-pass membrane protein.