Regulatory Network in Protein Phosphorylation
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Kinase: PDHK4 pyruvate dehydrogenase kinase, isozyme 4

Group: Atypical      Family: PDHK      Subfamily: PDHK

Description: pyruvate dehydrogenase kinase, isozyme 4

Gene Symbol: PDK4

Synonyms: FLJ40832

UniprotKB/SwissProt: PDK4_HUMAN (Q16654)

Function: Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

Subcellular Localization: Mitochondrion matrix.

Protein Domain:

The substrate proteins of kinase PDHK4

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1PDHA1ODPA_HUMANPyruvate dehydrogenase E1 component subunit alpha, somatic form,mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type I). 4Show



The substrate proteins of kinase family PDHK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1AKT1AKT1_HUMANRAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha)(Protein kinase B) (PKB) (C-AKT). 2Show
2AKT3AKT3_HUMANRAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma)(Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2). 1Show
3ITGB3ITB3_HUMANIntegrin beta-3 precursor (Platelet membrane glycoprotein IIIa)(GPIIIa) (CD61 antigen). 1Show
4PDHA1ODPA_HUMANPyruvate dehydrogenase E1 component subunit alpha, somatic form,mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type I). 11Show
5PDK1PDK1_HUMAN[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrialprecursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1). 3Show
6PKN2PKN2_HUMANSerine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2). 2Show