Regulatory Network in Protein Phosphorylation
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Kinase: FRAP FK506 binding protein 12-rapamycin associated protein 1

Group: Atypical      Family: PIKK      Subfamily: FRAP

Description: FK506 binding protein 12-rapamycin associated protein 1

Gene Symbol: FRAP1

Synonyms: FLJ44809, FRAP, FRAP2, MTOR, RAFT1, RAPT1

UniprotKB/SwissProt: FRAP_HUMAN (P42345)

Function: Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.

Subcellular Localization:

Protein Domain:
PDB:1AUE

The substrate proteins of kinase FRAP

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 11Show
2FRAP1FRAP_HUMANFKBP12-rapamycin complex-associated protein (FK506-binding protein 12-rapamycin complex-associated protein 1) (Rapamycin target protein)(RAPT1) (Mammalian target of rapamycin) (mTOR). 2Show
3RPS6KB1KS6B1_HUMANRibosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha). 7Show
4RPS6KB2KS6B2_HUMANRibosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDaribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinasebeta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14beta). 4Show



The substrate proteins of kinase family FRAP

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 11Show
2FRAP1FRAP_HUMANFKBP12-rapamycin complex-associated protein (FK506-binding protein 12-rapamycin complex-associated protein 1) (Rapamycin target protein)(RAPT1) (Mammalian target of rapamycin) (mTOR). 2Show
3RPS6KB1KS6B1_HUMANRibosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha). 7Show
4RPS6KB2KS6B2_HUMANRibosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDaribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinasebeta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14beta). 4Show