|Group: Atypical Family: PIKK Subfamily: FRAP|
Description: FK506 binding protein 12-rapamycin associated protein 1
Gene Symbol: FRAP1
Synonyms: FLJ44809, FRAP, FRAP2, MTOR, RAFT1, RAPT1
UniprotKB/SwissProt: FRAP_HUMAN (P42345)
Function: Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.