|Group: Atypical Family: TAF1 |
Description: TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
Gene Symbol: TAF1
Synonyms: BA2R, CCG1, CCGS, NSCL2, OF, P250, TAF2A, TAFII250
UniprotKB/SwissProt: TAF1_HUMAN (P21675)
Function: Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA- binding activity. Essential for progression of the G1 phase of the cell cycle.
Subcellular Localization: Nucleus.