Regulatory Network in Protein Phosphorylation
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Kinase: TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

Group: Atypical      Family: TAF1      

Description: TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

Gene Symbol: TAF1

Synonyms: BA2R, CCG1, CCGS, NSCL2, OF, P250, TAF2A, TAFII250

UniprotKB/SwissProt: TAF1_HUMAN (P21675)

Function: Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA- binding activity. Essential for progression of the G1 phase of the cell cycle.

Subcellular Localization: Nucleus.

Protein Domain:
PDB:1EQF

The substrate proteins of kinase TAF1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 1Show
2GTF2A1TF2AA_HUMANTranscription initiation factor IIA subunit 1 (General transcriptionfactor IIA1) (TFIIA-42) (TFIIAL) [Contains: Transcription initiationfactor IIA alpha chain (TFIIA p35 subunit); Transcription initiationfactor IIA beta chain (TFIIA p19 subunit)]. 8Show



The substrate proteins of kinase family TAF1

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 1Show
2GTF2A1TF2AA_HUMANTranscription initiation factor IIA subunit 1 (General transcriptionfactor IIA1) (TFIIA-42) (TFIIAL) [Contains: Transcription initiationfactor IIA alpha chain (TFIIA p35 subunit); Transcription initiationfactor IIA beta chain (TFIIA p19 subunit)]. 8Show