|Group: Atypical Family: TIF1 |
Description: tripartite motif-containing 28
Gene Symbol: TRIM28
Synonyms: FLJ29029, KAP1, RNF96, TF1B, TIF1B
UniprotKB/SwissProt: TIF1B_HUMAN (Q13263)
Function: Forms a complex with a KRAB-domain transcription factor and increases the efficiency of KRAB-mediated repression. Silences transcription through an interaction with HP1 proteins. Acts as a corepressor of transcription for the KRAB zinc finger proteins and as a moderator of the repression activity. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of the Alpha-1-acid glycoprotein gene (By similarity).
Subcellular Localization: Nucleus (By similarity). Note=Associated with centromeric heterochromatin during cell differentiation through CBX1 (By similarity).