Regulatory Network in Protein Phosphorylation
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Kinase: TIF1b tripartite motif-containing 28

Group: Atypical      Family: TIF1      

Description: tripartite motif-containing 28

Gene Symbol: TRIM28

Synonyms: FLJ29029, KAP1, RNF96, TF1B, TIF1B

UniprotKB/SwissProt: TIF1B_HUMAN (Q13263)

Function: Forms a complex with a KRAB-domain transcription factor and increases the efficiency of KRAB-mediated repression. Silences transcription through an interaction with HP1 proteins. Acts as a corepressor of transcription for the KRAB zinc finger proteins and as a moderator of the repression activity. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of the Alpha-1-acid glycoprotein gene (By similarity).

Subcellular Localization: Nucleus (By similarity). Note=Associated with centromeric heterochromatin during cell differentiation through CBX1 (By similarity).

Protein Domain:
PDB:1FP0