Regulatory Network in Protein Phosphorylation
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Kinase: TIF1g tripartite motif-containing 33

Group: Atypical      Family: TIF1      

Description: tripartite motif-containing 33

Gene Symbol: TRIM33

Synonyms: FLJ32925, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA

UniprotKB/SwissProt: TRI33_HUMAN (Q9UPN9)

Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity).

Subcellular Localization: Nucleus. Note=In discrete nuclear dots resembling nuclear bodies (By similarity).

Protein Domain: