|Group: Atypical Family: TIF1 |
Description: tripartite motif-containing 33
Gene Symbol: TRIM33
Synonyms: FLJ32925, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA
UniprotKB/SwissProt: TRI33_HUMAN (Q9UPN9)
Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity).
Subcellular Localization: Nucleus. Note=In discrete nuclear dots resembling nuclear bodies (By similarity).