Regulatory Network in Protein Phosphorylation
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Kinase: CaMK1d calcium/calmodulin-dependent protein kinase ID

Group: CAMK      Family: CAMK1      

Description: calcium/calmodulin-dependent protein kinase ID

Gene Symbol: CAMK1D

Synonyms: CKLiK, CaM-K1, CaMKID

UniprotKB/SwissProt: KCC1D_HUMAN (Q8IU85)

Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May regulate calcium-mediated granulocyte function. May play a role in apoptosis of erythroleukemia cells. Activates MAP kinase MAPK3 (By similarity). In vitro, phosphorylates transcription factor CREM isoform Beta and probably CREB1.

Subcellular Localization: Cytoplasm (Probable). Nucleus (Probable). Note=Predominantly cytoplasmic (Probable). Also nuclear upon activation (Probable).

Protein Domain:
PDB:2JC6

The substrate proteins of kinase family CAMK1

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ACACAACACA_HUMANAcetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotincarboxylase (EC 6.3.4.14)]. 1Show
2ATF1ATF1_HUMANCyclic AMP-dependent transcription factor ATF-1 (Activatingtranscription factor 1) (TREB36 protein). 2Show
3CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 1Show
4EP300EP300_HUMANHistone acetyltransferase p300 (EC 2.3.1.48) (E1A-associated proteinp300). 1Show
5HDAC5HDAC5_HUMANHistone deacetylase 5 (HD5) (Antigen NY-CO-9). 3Show
6EIF4G3IF4G3_HUMANEukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3)(eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII). 2Show
7KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 1Show
8CAMK1KCC1A_HUMANCalcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaMkinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha). 2Show
9CAMK4KCC4_HUMANCalcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17)(CAM kinase-GR) (CaMK IV). 1Show
10NOS1NOS1_HUMANNitric oxide synthase, brain (EC 1.14.13.39) (NOS type I) (NeuronalNOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS). 2Show
11CAMK2GQ8NIA4_HUMANCalcium/calmodulin-dependent protein kinase II gamma (Fragment). 1Show
12SYN1SYN1_HUMANSynapsin-1 (Synapsin I) (Brain protein 4.1). 3Show