Regulatory Network in Protein Phosphorylation
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Kinase: CaMK4 calcium/calmodulin-dependent protein kinase IV

Group: CAMK      Family: CAMK1      

Description: calcium/calmodulin-dependent protein kinase IV

Gene Symbol: CAMK4

Synonyms: CaMK-GR, MGC36771

UniprotKB/SwissProt: KCC4_HUMAN (Q16566)

Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory (By similarity).

Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity). Note=Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix (By similarity).

Protein Domain:

The substrate proteins of kinase CaMK4

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CALM1CALM_HUMANCalmodulin (CaM). 1Show
2CREBBPCBP_HUMANCREB-binding protein (EC 2Show
3CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 2Show
4EP300EP300_HUMANHistone acetyltransferase p300 (EC (E1A-associated proteinp300). 1Show
5HDAC4HDAC4_HUMANHistone deacetylase 4 (HD4). 7Show
6HDAC5HDAC5_HUMANHistone deacetylase 5 (HD5) (Antigen NY-CO-9). 2Show
7NOS1NOS1_HUMANNitric oxide synthase, brain (EC (NOS type I) (NeuronalNOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS). 2Show
8CAMK2GQ8NIA4_HUMANCalcium/calmodulin-dependent protein kinase II gamma (Fragment). 1Show

The substrate proteins of kinase family CAMK1

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ACACAACACA_HUMANAcetyl-CoA carboxylase 1 (EC (ACC-alpha) [Includes: Biotincarboxylase (EC]. 1Show
2ATF1ATF1_HUMANCyclic AMP-dependent transcription factor ATF-1 (Activatingtranscription factor 1) (TREB36 protein). 2Show
3CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 1Show
4EP300EP300_HUMANHistone acetyltransferase p300 (EC (E1A-associated proteinp300). 1Show
5HDAC5HDAC5_HUMANHistone deacetylase 5 (HD5) (Antigen NY-CO-9). 3Show
6EIF4G3IF4G3_HUMANEukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3)(eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII). 2Show
7KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 1Show
8CAMK1KCC1A_HUMANCalcium/calmodulin-dependent protein kinase type 1 (EC (CaMkinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha). 2Show
9CAMK4KCC4_HUMANCalcium/calmodulin-dependent protein kinase type IV (EC kinase-GR) (CaMK IV). 1Show
10NOS1NOS1_HUMANNitric oxide synthase, brain (EC (NOS type I) (NeuronalNOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS). 2Show
11CAMK2GQ8NIA4_HUMANCalcium/calmodulin-dependent protein kinase II gamma (Fragment). 1Show
12SYN1SYN1_HUMANSynapsin-1 (Synapsin I) (Brain protein 4.1). 3Show