Regulatory Network in Protein Phosphorylation
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Kinase: CaMK2a calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha

Group: CAMK      Family: CAMK2      

Description: calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha

Gene Symbol: CAMK2A

Synonyms: CAMKA, KIAA0968

UniprotKB/SwissProt: KCC2A_HUMAN (Q9UQM7)

Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).

Subcellular Localization: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity).

Protein Domain:

The substrate proteins of kinase CaMK2a

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ATP2A2AT2A2_HUMANSarcoplasmic/endoplasmic reticulum calcium ATPase 2 (EC 3.6.3.8)(Calcium pump 2) (SERCA2) (SR Ca(2+)-ATPase 2) (Calcium-transportingATPase sarcoplasmic reticulum type, slow twitch skeletal muscleisoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase). 1Show
2CEBPBCEBPB_HUMANCCAAT/enhancer-binding protein beta (C/EBP beta) (Nuclear factor NF-IL6) (Transcription factor 5). 1Show
3CLCN3CLCN3_HUMANChloride channel protein 3 (ClC-3). 1Show
4CPEB1CPEB1_HUMANCytoplasmic polyadenylation element-binding protein 1 (CPE-bindingprotein 1) (CPE-BP1) (hCPEB-1) (h-CEBP). 1Show
5DLG1DLG1_HUMANDisks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg). 1Show
6EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC 2.7.10.1) (Receptortyrosine-protein kinase ErbB-1). 12Show
7ERBB2ERBB2_HUMANReceptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1)(p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cellsurface receptor HER2) (MLN 19) (CD340 antigen). 1Show
8ETS1ETS1_HUMANProtein C-ets-1 (p54). 8Show
9GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 4Show
10HRH1HRH1_HUMANHistamine H1 receptor. 4Show
11HSF1HSF1_HUMANHeat shock factor protein 1 (HSF 1) (Heat shock transcription factor1) (HSTF 1). 2Show
12ITPKAIP3KA_HUMANInositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A). 1Show
13ITGB1BP1ITBP1_HUMANIntegrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1). 2Show
14KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 1Show
15CAMK2AKCC2A_HUMANCalcium/calmodulin-dependent protein kinase type II alpha chain(EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II subunitalpha) (CaMK-II subunit alpha). 4Show
16ALOX5LOX5_HUMANArachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO). 1Show
17LRRC7LRRC7_HUMANLeucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180). 1Show
18GRIN2ANMDE1_HUMANGlutamate [NMDA] receptor subunit epsilon-1 precursor (N-methyl D-aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A). 1Show
19GRIN2BNMDE2_HUMANGlutamate [NMDA] receptor subunit epsilon-2 precursor (N-methyl D-aspartate receptor subtype 2B) (NR2B) (NMDAR2B) (N-methyl-D-aspartatereceptor subunit 3) (NR3) (hNR3). 2Show
20NOS1NOS1_HUMANNitric oxide synthase, brain (EC 1.14.13.39) (NOS type I) (NeuronalNOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS). 2Show
21PLA2G4APA24A_HUMANCytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA)[Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]. 1Show
22PDCPHOS_HUMANPhosducin (PHD) (33 kDa phototransducing protein) (MEKA protein). 2Show
23PLCB3PLCB3_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3(EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C-beta-3) (PLC-beta-3). 1Show
24PPP1R14APP14A_HUMANProtein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiatedinhibitory protein of PP1) (CPI-17). 1Show
25RYR2RYR2_HUMANRyanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2)(RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel)(hRYR-2). 1Show
26SMAD2SMAD2_HUMANMothers against decapentaplegic homolog 2 (SMAD 2) (Mothers againstDPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2). 3Show
27SRFSRF_HUMANSerum response factor (SRF). 2Show
28MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 2Show
29THTY3H_HUMANTyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH). 2Show
30VIMVIME_HUMANVimentin. 1Show



The substrate proteins of kinase family CAMK2

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ADCY3ADCY3_HUMANAdenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III)(ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3)(Adenylate cyclase, olfactive type). 2Show
2ATP2A2AT2A2_HUMANSarcoplasmic/endoplasmic reticulum calcium ATPase 2 (EC 3.6.3.8)(Calcium pump 2) (SERCA2) (SR Ca(2+)-ATPase 2) (Calcium-transportingATPase sarcoplasmic reticulum type, slow twitch skeletal muscleisoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase). 2Show
3ATF1ATF1_HUMANCyclic AMP-dependent transcription factor ATF-1 (Activatingtranscription factor 1) (TREB36 protein). 1Show
4CEBPBCEBPB_HUMANCCAAT/enhancer-binding protein beta (C/EBP beta) (Nuclear factor NF-IL6) (Transcription factor 5). 2Show
5CLCN3CLCN3_HUMANChloride channel protein 3 (ClC-3). 1Show
6CFL2COF2_HUMANCofilin-2 (Cofilin, muscle isoform). 1Show
7CPEB1CPEB1_HUMANCytoplasmic polyadenylation element-binding protein 1 (CPE-bindingprotein 1) (CPE-BP1) (hCPEB-1) (h-CEBP). 1Show
8CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 4Show
9CREMCREM_HUMANcAMP-responsive element modulator (Inducible cAMP early repressor)(ICER). 2Show
10QDPRDHPR_HUMANDihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoiddihydropteridine reductase). 1Show
11DLG1DLG1_HUMANDisks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg). 2Show
12EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC 2.7.10.1) (Receptortyrosine-protein kinase ErbB-1). 14Show
13ERBB2ERBB2_HUMANReceptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1)(p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cellsurface receptor HER2) (MLN 19) (CD340 antigen). 1Show
14ETS1ETS1_HUMANProtein C-ets-1 (p54). 12Show
15FLNAFLNA_HUMANFilamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-bindingprotein) (Actin-binding protein 280) (ABP-280) (Non-muscle filamin). 2Show
16GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 7Show
17GRIA1GRIA1_HUMANGlutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamatereceptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1). 3Show
18GRIA4GRIA4_HUMANGlutamate receptor 4 precursor (GluR-4) (GluR4) (GluR-D) (Glutamatereceptor ionotropic, AMPA 4) (AMPA-selective glutamate receptor 4). 1Show
19HRH1HRH1_HUMANHistamine H1 receptor. 4Show
20HSF1HSF1_HUMANHeat shock factor protein 1 (HSF 1) (Heat shock transcription factor1) (HSTF 1). 2Show
21ITPKAIP3KA_HUMANInositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A). 1Show
22ITGB1BP1ITBP1_HUMANIntegrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1). 2Show
23KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 2Show
24KRT8K2C8_HUMANKeratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8)(K8). 2Show
25CAMK2AKCC2A_HUMANCalcium/calmodulin-dependent protein kinase type II alpha chain(EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II subunitalpha) (CaMK-II subunit alpha). 4Show
26CAMK2BKCC2B_HUMANCalcium/calmodulin-dependent protein kinase type II beta chain(EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta)(CaMK-II subunit beta). 1Show
27KCND2KCND2_HUMANPotassium voltage-gated channel subfamily D member 2 (Voltage-gatedpotassium channel subunit Kv4.2). 2Show
28ALOX5LOX5_HUMANArachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO). 1Show
29LRRC7LRRC7_HUMANLeucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180). 1Show
30MYLKMYLK_HUMANMyosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK)(Telokin) (Kinase-related protein) (KRP). 1Show
31GRIN2ANMDE1_HUMANGlutamate [NMDA] receptor subunit epsilon-1 precursor (N-methyl D-aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A). 2Show
32GRIN2BNMDE2_HUMANGlutamate [NMDA] receptor subunit epsilon-2 precursor (N-methyl D-aspartate receptor subtype 2B) (NR2B) (NMDAR2B) (N-methyl-D-aspartatereceptor subunit 3) (NR3) (hNR3). 4Show
33NOS1NOS1_HUMANNitric oxide synthase, brain (EC 1.14.13.39) (NOS type I) (NeuronalNOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS). 2Show
34PLA2G4APA24A_HUMANCytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA)[Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]. 1Show
35PEA15PEA15_HUMANAstrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes)(PED). 2Show
36PDCPHOS_HUMANPhosducin (PHD) (33 kDa phototransducing protein) (MEKA protein). 2Show
37PLCB3PLCB3_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3(EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C-beta-3) (PLC-beta-3). 3Show
38PPP1R14APP14A_HUMANProtein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiatedinhibitory protein of PP1) (CPI-17). 2Show
39RRADRAD_HUMANGTP-binding protein RAD (RAS associated with diabetes) (RAD1). 1Show
40RYR1RYR1_HUMANRyanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1)(RYR-1) (Skeletal muscle calcium release channel). 1Show
41RYR2RYR2_HUMANRyanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2)(RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel)(hRYR-2). 1Show
42SMAD2SMAD2_HUMANMothers against decapentaplegic homolog 2 (SMAD 2) (Mothers againstDPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2). 4Show
43SPRSPRE_HUMANSepiapterin reductase (EC 1.1.1.153) (SPR). 2Show
44SRFSRF_HUMANSerum response factor (SRF). 2Show
45STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 1Show
46SYN1SYN1_HUMANSynapsin-1 (Synapsin I) (Brain protein 4.1). 4Show
47SNCGSYUG_HUMANGamma-synuclein (Persyn) (Breast cancer-specific gene 1 protein)(Synoretin) (SR). 1Show
48MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 3Show
49THTY3H_HUMANTyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH). 3Show
50VIMVIME_HUMANVimentin. 4Show
51VPS72VPS72_HUMANVacuolar protein sorting-associated protein 72 homolog (Transcriptionfactor-like 1) (Protein YL-1). 3Show