Regulatory Network in Protein Phosphorylation
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Kinase: AMPKa2 protein kinase, AMP-activated, alpha 2 catalytic subunit

Group: CAMK      Family: CAMKL      Subfamily: AMPK

Description: protein kinase, AMP-activated, alpha 2 catalytic subunit

Gene Symbol: PRKAA2

Synonyms: AMPK, AMPK2, PRKAA

UniprotKB/SwissProt: AAPK2_HUMAN (P54646)

Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

Subcellular Localization:

Protein Domain:
PDB:2H6D

The substrate proteins of kinase AMPKa2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ACACAACACA_HUMANAcetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotincarboxylase (EC 6.3.4.14)]. 1Show
2ACACBACACB_HUMANAcetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotincarboxylase (EC 6.3.4.14)]. 1Show
3EEF2KEF2K_HUMANElongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). 3Show
4PFKFB2F262_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru-2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase(EC 3.1.3.46)]. 1Show
5HNF4AHNF4A_HUMANHepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factorHNF-4) (Nuclear receptor subfamily 2 group A member 1) (Transcriptionfactor 14). 1Show



The substrate proteins of kinase family AMPK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1PRKAA1AAPK1_HUMAN5'-AMP-activated protein kinase catalytic subunit alpha-1(EC 2.7.11.1) (AMPK alpha-1 chain). 1Show
2PRKAA2AAPK2_HUMAN5'-AMP-activated protein kinase catalytic subunit alpha-2(EC 2.7.11.1) (AMPK alpha-2 chain). 1Show
3ACACAACACA_HUMANAcetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotincarboxylase (EC 6.3.4.14)]. 7Show
4ACACBACACB_HUMANAcetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotincarboxylase (EC 6.3.4.14)]. 2Show
5CASP6CASP6_HUMANCaspase-6 precursor (EC 3.4.22.59) (CASP-6) (Apoptotic protease Mch-2)[Contains: Caspase-6 subunit p18; Caspase-6 subunit p11]. 1Show
6EEF2KEF2K_HUMANElongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). 9Show
7EP300EP300_HUMANHistone acetyltransferase p300 (EC 2.3.1.48) (E1A-associated proteinp300). 1Show
8PFKFB2F262_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru-2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase(EC 3.1.3.46)]. 3Show
9PFKFB3F263_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) (Renal carcinomaantigen NY-REN-56) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105);Fructose-2,6-bisphosphatase (EC 3.1.3.46)]. 1Show
10GRIK2GRIK2_HUMANGlutamate receptor, ionotropic kainate 2 precursor (Glutamate receptor6) (GluR-6) (GluR6) (Excitatory amino acid receptor 4) (EAA4). 1Show
11HNF4AHNF4A_HUMANHepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factorHNF-4) (Nuclear receptor subfamily 2 group A member 1) (Transcriptionfactor 14). 2Show
12KPNA2IMA2_HUMANImportin subunit alpha-2 (Karyopherin subunit alpha-2) (SRP1-alpha)(RAG cohort protein 1). 1Show
13LIPELIPS_HUMANHormone-sensitive lipase (EC 3.1.1.79) (HSL). 1Show
14NOS3NOS3_HUMANNitric oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS typeIII) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS). 1Show
15RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 3Show