Regulatory Network in Protein Phosphorylation
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Kinase: BRSK1 BR serine/threonine kinase 1

Group: CAMK      Family: CAMKL      Subfamily: BRSK

Description: BR serine/threonine kinase 1

Gene Symbol: BRSK1

Synonyms: FLJ43009, KIAA1811

UniprotKB/SwissProt: BRSK1_HUMAN (Q8TDC3)

Function: Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)- induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.

Subcellular Localization: Cytoplasm. Nucleus. Note=Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.

Protein Domain:

The substrate proteins of kinase BRSK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CDC25BMPIP2_HUMANM-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25B). 1Show
2CDC25CMPIP3_HUMANM-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25C). 3Show
3WEE1WEE1_HUMANWee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). 2Show



The substrate proteins of kinase family BRSK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CDC25BMPIP2_HUMANM-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25B). 1Show
2CDC25CMPIP3_HUMANM-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25C). 4Show
3WEE1WEE1_HUMANWee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). 3Show