Regulatory Network in Protein Phosphorylation
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Kinase: LKB1 serine/threonine kinase 11

Group: CAMK      Family: CAMKL      Subfamily: LKB

Description: serine/threonine kinase 11

Gene Symbol: STK11

Synonyms: LKB1, PJS

UniprotKB/SwissProt: STK11_HUMAN (Q15831)

Function: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.

Subcellular Localization: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.

Protein Domain:

The substrate proteins of kinase LKB1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1PRKAA1AAPK1_HUMAN5'-AMP-activated protein kinase catalytic subunit alpha-1(EC 2.7.11.1) (AMPK alpha-1 chain). 2Show
2PRKAA2AAPK2_HUMAN5'-AMP-activated protein kinase catalytic subunit alpha-2(EC 2.7.11.1) (AMPK alpha-2 chain). 1Show
3BRSK1BRSK1_HUMANBR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase)(Serine/threonine kinase SAD-B). 1Show
4BRSK2BRSK2_HUMANBR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine-protein kinase 29) (Serine/threonine kinase SAD-A). 1Show
5MARK1MARK1_HUMANSerine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubuleaffinity-regulating kinase 1). 3Show
6MARK2MARK2_HUMANSerine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubuleaffinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1homolog). 1Show
7MARK3MARK3_HUMANMAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonineprotein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinaseSTK10). 1Show
8MARK4MARK4_HUMANMAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)(MAP/microtubule affinity-regulating kinase-like 1). 1Show
9MELKMELK_HUMANMaternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK)(Protein kinase PK38) (hPK38). 1Show
10NUAK1NUAK1_HUMANNUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related proteinkinase 5). 1Show
11NUAK2NUAK2_HUMANNUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-relatedkinase) (SNARK). 1Show
12PTENPTEN_HUMANPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1). 1Show
13QSKQSK_HUMANSerine/threonine-protein kinase QSK (EC 2.7.11.1) (Salt-induciblekinase 3) (SIK-3) (SIK3). 1Show
14SNF1LKSN1L1_HUMANSerine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1)(Serine/threonine-protein kinase SNF1LK) (Salt-inducible kinase 1)(SIK-1) (SIK1). 1Show
15SNF1LK2SN1L2_HUMANSerine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible protein kinase 2) (SIK-2) (SIK2). 1Show
16SNRKSNRK_HUMANSNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase). 2Show
17STK11STK11_HUMANSerine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine-protein kinase LKB1) (Renal carcinoma antigen NY-REN-19). 2Show
18STRADSTRAD_HUMANSTE20-related adapter protein (STRAD alpha) (Serologically definedbreast cancer antigen NY-BR-96). 2Show



The substrate proteins of kinase family LKB

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1PRKAA1AAPK1_HUMAN5'-AMP-activated protein kinase catalytic subunit alpha-1(EC 2.7.11.1) (AMPK alpha-1 chain). 2Show
2PRKAA2AAPK2_HUMAN5'-AMP-activated protein kinase catalytic subunit alpha-2(EC 2.7.11.1) (AMPK alpha-2 chain). 1Show
3BRSK1BRSK1_HUMANBR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase)(Serine/threonine kinase SAD-B). 1Show
4BRSK2BRSK2_HUMANBR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine-protein kinase 29) (Serine/threonine kinase SAD-A). 1Show
5MARK1MARK1_HUMANSerine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubuleaffinity-regulating kinase 1). 3Show
6MARK2MARK2_HUMANSerine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubuleaffinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1homolog). 1Show
7MARK3MARK3_HUMANMAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonineprotein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinaseSTK10). 1Show
8MARK4MARK4_HUMANMAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)(MAP/microtubule affinity-regulating kinase-like 1). 1Show
9MELKMELK_HUMANMaternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK)(Protein kinase PK38) (hPK38). 1Show
10NUAK1NUAK1_HUMANNUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related proteinkinase 5). 1Show
11NUAK2NUAK2_HUMANNUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-relatedkinase) (SNARK). 1Show
12PTENPTEN_HUMANPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1). 1Show
13QSKQSK_HUMANSerine/threonine-protein kinase QSK (EC 2.7.11.1) (Salt-induciblekinase 3) (SIK-3) (SIK3). 1Show
14SNF1LKSN1L1_HUMANSerine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1)(Serine/threonine-protein kinase SNF1LK) (Salt-inducible kinase 1)(SIK-1) (SIK1). 1Show
15SNF1LK2SN1L2_HUMANSerine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible protein kinase 2) (SIK-2) (SIK2). 1Show
16SNRKSNRK_HUMANSNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase). 2Show
17STK11STK11_HUMANSerine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine-protein kinase LKB1) (Renal carcinoma antigen NY-REN-19). 2Show
18STRADSTRAD_HUMANSTE20-related adapter protein (STRAD alpha) (Serologically definedbreast cancer antigen NY-BR-96). 2Show