Regulatory Network in Protein Phosphorylation
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Kinase: LKB1 serine/threonine kinase 11

Group: CAMK      Family: CAMKL      Subfamily: LKB

Description: serine/threonine kinase 11

Gene Symbol: STK11

Synonyms: LKB1, PJS

UniprotKB/SwissProt: STK11_HUMAN (Q15831)

Function: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.

Subcellular Localization: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.

Protein Domain:

The substrate proteins of kinase LKB1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1PRKAA1AAPK1_HUMAN5'-AMP-activated protein kinase catalytic subunit alpha-1(EC 2.7.11.1) (AMPK alpha-1 chain). 2Show
2PRKAA2AAPK2_HUMAN5'-AMP-activated protein kinase catalytic subunit alpha-2(EC 2.7.11.1) (AMPK alpha-2 chain). 1Show
3BRSK1BRSK1_HUMANBR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase)(Serine/threonine kinase SAD-B). 1Show
4BRSK2BRSK2_HUMANBR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine-protein kinase 29) (Serine/threonine kinase SAD-A). 1Show
5MARK1MARK1_HUMANSerine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubuleaffinity-regulating kinase 1). 3Show
6MARK2MARK2_HUMANSerine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubuleaffinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1homolog). 1Show
7MARK3MARK3_HUMANMAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonineprotein kinase p78) (Ser/Thr protein