Regulatory Network in Protein Phosphorylation
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Kinase: MARK2 MAP/microtubule affinity-regulating kinase 2

Group: CAMK      Family: CAMKL      Subfamily: MARK

Description: MAP/microtubule affinity-regulating kinase 2

Gene Symbol: MARK2

Synonyms: EMK1, MGC99619, PAR-1

UniprotKB/SwissProt: MARK2_HUMAN (Q7KZI7)

Function: Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.

Subcellular Localization: Cell membrane; Peripheral membrane protein. Note=Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.

Protein Domain:

The substrate proteins of kinase family MARK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1KSR1KSR1_HUMANKinase suppressor of Ras 1. 1Show
2KSR2KSR2_HUMANKinase suppressor of Ras 2 (hKSR2). 1Show
3MAP2MAP2_HUMANMicrotubule-associated protein 2 (MAP 2) (MAP-2). 7Show
4MAP4MAP4_HUMANMicrotubule-associated protein 4 (MAP 4). 5Show
5CDC25CMPIP3_HUMANM-phase inducer phosphatase 3 (EC (Dual specificityphosphatase Cdc25C). 1Show
6MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 12Show