Regulatory Network in Protein Phosphorylation
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Kinase: NuaK2 NUAK family, SNF1-like kinase, 2

Group: CAMK      Family: CAMKL      Subfamily: NuaK

Description: NUAK family, SNF1-like kinase, 2

Gene Symbol: NUAK2

Synonyms: DKFZP434J037, DKFZp686F01113, FLJ90349, SNARK

UniprotKB/SwissProt: NUAK2_HUMAN (Q9H093)

Function: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase NuaK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CRTC1CRTC1_HUMANCREB-regulated transcription coactivator 1 (Transducer of regulatedcAMP response element-binding protein 1) (TORC-1) (Transducer of CREBprotein 1) (Mucoepidermoid carcinoma translocated protein 1). 1Show
2CRTC2CRTC2_HUMANCREB-regulated transcription coactivator 2 (Transducer of regulatedcAMP response element-binding protein 2) (TORC-2) (Transducer of CREBprotein 2). 1Show
3CRTC3CRTC3_HUMANCREB-regulated transcription coactivator 3 (Transducer of regulatedcAMP response element-binding protein 3) (TORC-3) (Transducer of CREBprotein 3). 1Show
4IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 1Show



The substrate proteins of kinase family NuaK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CASP6CASP6_HUMANCaspase-6 precursor (EC 3.4.22.59) (CASP-6) (Apoptotic protease Mch-2)[Contains: Caspase-6 subunit p18; Caspase-6 subunit p11]. 2Show
2CRTC1CRTC1_HUMANCREB-regulated transcription coactivator 1 (Transducer of regulatedcAMP response element-binding protein 1) (TORC-1) (Transducer of CREBprotein 1) (Mucoepidermoid carcinoma translocated protein 1). 1Show
3CRTC2CRTC2_HUMANCREB-regulated transcription coactivator 2 (Transducer of regulatedcAMP response element-binding protein 2) (TORC-2) (Transducer of CREBprotein 2). 1Show
4CRTC3CRTC3_HUMANCREB-regulated transcription coactivator 3 (Transducer of regulatedcAMP response element-binding protein 3) (TORC-3) (Transducer of CREBprotein 3). 1Show
5IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 1Show