Regulatory Network in Protein Phosphorylation
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Kinase: SIK SNF1-like kinase

Group: CAMK      Family: CAMKL      Subfamily: QIK

Description: SNF1-like kinase

Gene Symbol: SNF1LK

Synonyms: MSK, SIK

UniprotKB/SwissProt: SN1L1_HUMAN (P57059)

Function: Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3 (By similarity).

Subcellular Localization: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.

Protein Domain:

The substrate proteins of kinase SIK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 1Show



The substrate proteins of kinase family QIK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 1Show