Regulatory Network in Protein Phosphorylation
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Kinase: CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Group: CAMK      Family: CASK      

Description: calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Gene Symbol: CASK

Synonyms: LIN2

UniprotKB/SwissProt: CSKP_HUMAN (O14936)

Function: Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

Subcellular Localization: Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity).

Protein Domain:
PDB:1KGD