|Group: CAMK Family: CASK |
Description: calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Gene Symbol: CASK
UniprotKB/SwissProt: CSKP_HUMAN (O14936)
Function: Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
Subcellular Localization: Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity).