Regulatory Network in Protein Phosphorylation
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Kinase: DAPK3 death-associated protein kinase 3

Group: CAMK      Family: DAPK      Subfamily: DAPK

Description: death-associated protein kinase 3

Gene Symbol: DAPK3

Synonyms: FLJ36473, ZIP, ZIPK

UniprotKB/SwissProt: DAPK3_HUMAN (O43293)

Function: Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis.

Subcellular Localization: Nucleus. Cytoplasm (By similarity). Note=Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (By similarity). Associates to centromeres from prophase to anaphase.

Protein Domain:
PDB:1YRP

The substrate proteins of kinase DAPK3

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 3Show
2DAPK3DAPK3_HUMANDeath-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase). 6Show
3HIST1H3AH31_HUMANHistone H3.1 (H3/a) (H3/b) (H3/c) (H3/d) (H3/f) (H3/h) (H3/i) (H3/j)(H3/k) (H3/l). 1Show
4MDM2MDM2_HUMANE3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (p53-binding proteinMdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2). 1Show
5MYL9MLRN_HUMANMyosin regulatory light chain 2, smooth muscle isoform (Myosin RLC)(Myosin regulatory light chain 9) (LC20). 2Show
6PPP1R14APP14A_HUMANProtein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiatedinhibitory protein of PP1) (CPI-17). 2Show



The substrate proteins of kinase family DAPK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 3Show
2DAPK1DAPK1_HUMANDeath-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1). 2Show
3DAPK2DAPK2_HUMANDeath-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP-kinase-related protein 1) (DRP-1). 2Show
4DAPK3DAPK3_HUMANDeath-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase). 6Show
5HIST1H3AH31_HUMANHistone H3.1 (H3/a) (H3/b) (H3/c) (H3/d) (H3/f) (H3/h) (H3/i) (H3/j)(H3/k) (H3/l). 1Show
6CAMKK2KKCC2_HUMANCalcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17)(Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinasekinase beta) (CaM-KK beta) (CaMKK beta). 1Show
7MDM2MDM2_HUMANE3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (p53-binding proteinMdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2). 1Show
8MYL9MLRN_HUMANMyosin regulatory light chain 2, smooth muscle isoform (Myosin RLC)(Myosin regulatory light chain 9) (LC20). 2Show
9PPP1R14APP14A_HUMANProtein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiatedinhibitory protein of PP1) (CPI-17). 2Show
10STX1ASTX1A_HUMANSyntaxin-1A (Neuron-specific antigen HPC-1). 2Show