Regulatory Network in Protein Phosphorylation
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Kinase: MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2

Group: CAMK      Family: MAPKAPK      Subfamily: MAPKAPK

Description: mitogen-activated protein kinase-activated protein kinase 2

Gene Symbol: MAPKAPK2

Synonyms: -

UniprotKB/SwissProt: MAPK2_HUMAN (P49137)

Function: Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.

Subcellular Localization:

Protein Domain:
PDB:1KWP