Regulatory Network in Protein Phosphorylation
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Kinase: MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3

Group: CAMK      Family: MAPKAPK      Subfamily: MAPKAPK

Description: mitogen-activated protein kinase-activated protein kinase 3

Gene Symbol: MAPKAPK3

Synonyms: 3PK, MAPKAP3

UniprotKB/SwissProt: MAPK3_HUMAN (Q16644)

Function: Modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK. Substrate of CSBP. In vitro, phosphorylates HSPB1, BMI1/PCGF4 and TCF3.

Subcellular Localization: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.

Protein Domain:

The substrate proteins of kinase MAPKAPK3

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1RCSD1CPZIP_HUMANCapz-interacting protein (Protein kinase substrate CapZIP) (RCSDdomain-containing protein 1). 2Show
2EEF2KEF2K_HUMANElongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). 1Show
3HSPB1HSPB1_HUMANHeat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27)(Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDaprotein) (28 kDa heat shock protein). 3Show



The substrate proteins of kinase family MAPKAPK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 1Show
2BAG2BAG2_HUMANBAG family molecular chaperone regulator 2 (Bcl-2-associatedathanogene 2) (BAG-2). 2Show
3RCSD1CPZIP_HUMANCapz-interacting protein (Protein kinase substrate CapZIP) (RCSDdomain-containing protein 1). 2Show
4CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 2Show
5EEF2KEF2K_HUMANElongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). 4Show
6ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 1Show
7ETV1ETV1_HUMANETS translocation variant 1 (Protein ER81). 2Show
8HSF1HSF1_HUMANHeat shock factor protein 1 (HSF 1) (Heat shock transcription factor1) (HSTF 1). 1Show
9HSPB1HSPB1_HUMANHeat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27)(Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDaprotein) (28 kDa heat shock protein). 9Show
10ALOX5LOX5_HUMANArachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO). 3Show
11LSP1LSP1_HUMANLymphocyte-specific protein 1 (Protein pp52) (52 kDa phosphoprotein)(Lymphocyte-specific antigen WP34) (47 kDa actin-binding protein). 5Show
12MAPKAPK2MAPK2_HUMANMAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activatedprotein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2). 1Show
13CDC25BMPIP2_HUMANM-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25B). 1Show
14NCOA1NCOA1_HUMANNuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroidreceptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (Renalcarcinoma antigen NY-REN-52). 2Show
15PLA2G4APA24A_HUMANCytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA)[Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]. 1Show
16SRFSRF_HUMANSerum response factor (SRF). 2Show
17TSC2TSC2_HUMANTuberin (Tuberous sclerosis 2 protein). 2Show
18ZFP36TTP_HUMANTristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36)(Protein TIS11A) (TIS11) (Growth factor-inducible nuclear proteinNUP475) (G0/G1 switch regulatory protein 24). 3Show
19THTY3H_HUMANTyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH). 5Show
20VIMVIME_HUMANVimentin. 4Show