Regulatory Network in Protein Phosphorylation
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Kinase: MNK1 MAP kinase interacting serine/threonine kinase 1

Group: CAMK      Family: MAPKAPK      Subfamily: MNK

Description: MAP kinase interacting serine/threonine kinase 1

Gene Symbol: MKNK1

Synonyms: MNK1

UniprotKB/SwissProt: MKNK1_HUMAN (Q9BUB5)

Function: May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Subcellular Localization: Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Nucleus.

Protein Domain:
PDB:2HW6

The substrate proteins of kinase MNK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1EIF4EIF4E_HUMANEukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNAcap-binding protein) (eIF-4F 25 kDa subunit). 2Show
2PLA2G4APA24A_HUMANCytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA)[Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]. 1Show



The substrate proteins of kinase family MNK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1EIF4EIF4E_HUMANEukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNAcap-binding protein) (eIF-4F 25 kDa subunit). 3Show
2PLA2G4APA24A_HUMANCytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA)[Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]. 1Show